Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells
文献类型：期刊论文
| 作者 | Liu, Zixuan; Zhu, Qiushuang; Song, Erqun; Song, Yang |
| 刊名 | TOXICOLOGY
 |
| 出版日期 | 2021-06-15 |
| 卷号 | 457页码:- |
| 关键词 | Polybrominated diphenyl ethers Quinone DNA damage Apoptosis Cell cycle arrest |
| ISSN号 | 0300-483X |
| 英文摘要 | Polybrominated diphenyl ethers (PBDEs) are world-wide used flame retardants before they were listed as Persistent Organic Pollutants (POPs) by the Stockholm Convention. Previously, our studies indicated that a quinone type of PBDE metabolite (PBDEQ) exposure was linked with neurotoxicity via excess free radical formation and oxidative stress. However, it is current unknown the effect of PBDEQ on genetic biomacromolecules DNA and corresponding biological consequences in neurological cells. Here, by employing phosphorylated histone H2AX in Serine 139 (gamma-H2AX) and comet assay in microglia BV2 cells, our data suggested PBDEQ could triggered DNA damage. Furthermore, PBDEQ exposure led to the caspase 3-dependent cell apoptosis. Moreover, PBDEQ induced G2/M-phase cell arrest in a p53-dependent manner. Notably, p53 activation coordinated cell cycle progression, alleviated DNA damage and ultimately mitigated apoptosis in BV2 cells. Finally, antioxidant N-acetyl-L-cysteine (NAC) inhibited p53 activation upon PBDEQ exposure, and then ameliorated PBDEQ-induced DNA damage, cell cycle arrest and apoptosis, which illustrated that PBDEQ-induced DNA damage and p53 activation were mediated by reactive oxygen species (ROS). Together, the current findings unveil the fundamental toxicological mechanisms of PBDEQ, which propose a potential therapeutic strategy against the adverse effect caused by PBDE exposure. |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45815]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Southwest Univ, Key Lab Luminescence Anal & Mol Sensing, Coll Pharmaceut Sci, Minist Educ, Chongqing 400715, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zixuan,Zhu, Qiushuang,Song, Erqun,et al. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells[J]. TOXICOLOGY,2021,457:-. |
| APA | Liu, Zixuan,Zhu, Qiushuang,Song, Erqun,&Song, Yang.(2021).Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells.TOXICOLOGY,457,-. |
| MLA | Liu, Zixuan,et al."Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells".TOXICOLOGY 457(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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