Polychlorinated biphenyl congener 180 (PCB 180) regulates mitotic clonal expansion and enhances adipogenesis through modulation of C/EBP beta SUMOylation in preadipocytes
文献类型：期刊论文
| 作者 | Yu, Caixia; Wen, Qing; Ren, Qidong; Du, Yuguo; Xie, Xinni |
| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
 |
| 出版日期 | 2021-06 |
| 卷号 | 152页码:- |
| 关键词 | PCB 180 Obesogen Mitotic clonal expansion (MCE) C/EBP beta SUMOylation Adipogenesis |
| ISSN号 | 0278-6915 |
| 英文摘要 | PCB 180 is a typical non-dioxin-like polychlorinated biphenyl (NDL-PCB). It is one of the most prevalent PCB-congeners found in human adipose tissue. However, the role of PCB 180 in obesity remains poorly understood. The aim of this study was to explore the adipogenic effect and mechanism of PCB 180. Significant enhancement in adipogenesis was observed when differentiating murine 3T3-L1 preadipocytes or human preadipocytes-visceral (HPA-v) that were exposed to PCB 180. Furthermore, exposure to PCB 180 during the first two days was critical to the adipogenic effect. According to results from sequential cell cycle analyses, cell counting, BrdU incorporation, and cyclin D1, cyclin B1, and p27 protein quantification, PCB 180 was found to enhance mitotic clonal expansion (MCE) during early adipogenic differentiation. Molecular mechanistic investigation revealed that PCB 180 promoted accumulation of the C/EBP beta protein, a key regulator that controls MCE. Finally, it was found that PCB 180 mitigated degradation of the C/EBP beta protein by repressing the SUMOylation and subsequent ubiquitination of C/EBP beta by the upregulation of SENP2. In summary, it was shown for the first time that PCB 180 facilitated adipogenesis by alleviating C/EBP beta protein SUMOylation. This result provides novel evidence regarding obesogenic effect of PCB 180. |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45817]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Chem Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Caixia,Wen, Qing,Ren, Qidong,et al. Polychlorinated biphenyl congener 180 (PCB 180) regulates mitotic clonal expansion and enhances adipogenesis through modulation of C/EBP beta SUMOylation in preadipocytes[J]. FOOD AND CHEMICAL TOXICOLOGY,2021,152:-. |
| APA | Yu, Caixia,Wen, Qing,Ren, Qidong,Du, Yuguo,&Xie, Xinni.(2021).Polychlorinated biphenyl congener 180 (PCB 180) regulates mitotic clonal expansion and enhances adipogenesis through modulation of C/EBP beta SUMOylation in preadipocytes.FOOD AND CHEMICAL TOXICOLOGY,152,-. |
| MLA | Yu, Caixia,et al."Polychlorinated biphenyl congener 180 (PCB 180) regulates mitotic clonal expansion and enhances adipogenesis through modulation of C/EBP beta SUMOylation in preadipocytes".FOOD AND CHEMICAL TOXICOLOGY 152(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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