Spontaneous formation of beta-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta
文献类型：期刊论文
| 作者 | Sun, Yunxiang; Kakinen, Aleksandr; Wan, Xulin; Moriarty, Niamh; Hunt, Cameron P. J.; Li, Yuhuan; Andrikopoulos, Nicholas; Nandakumar, Aparna; Davis, Thomas P.; Parish, Clare L. |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2021-06 |
| 卷号 | 38页码:- |
| 关键词 | A beta aggregation beta-barrel Oligomer Discrete molecular dynamics simulation Alzheimer's disease |
| ISSN号 | 1748-0132 |
| 英文摘要 | Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we performed the first synergic in silico, in vitro and in vivo validations of the structure, dynamics and toxicity of A beta 42 oligomers. A beta peptides readily assembled into beta-rich oligomers comprised of extended beta-hairpins and beta-strands. Nanosized beta-barrels were observed with certainty with simulations, transmission electron microscopy and Fourier transform infrared spectroscopy, corroborated by immunohistochemistry, cell viability, apoptosis, inflammation, autophagy and animal behavior assays. Secondary and tertiary structural properties of these oligomers, such as the sequence regions with high beta-sheet propensities and inter-residue contact frequency patterns, were similar to the properties known for A beta fibrils. The unambiguous spontaneous formation of beta-barrels in the early aggregation of A beta 42 supports their roles as the common toxic intermediates in Alzheimer pathobiology and a target for Alzheimers therapeutics. (C) 2021 Elsevier Ltd. All rights reserved. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45843]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Ningbo Univ, Sch Phys Sci & Technol, Ningbo 315211, Peoples R China 2.Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia 3.Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA 4.Fudan Univ, Zhongshan Hosp, 111 Yixueyuan Rd, Shanghai 200032, Peoples R China 5.Univ Melbourne, Florey Inst Neurosci & Mental Hlth, 30 Royal Parade, Parkville, Vic 3052, Australia 6.Southwest Univ, Coll Food Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, 2 Tiansheng Rd, Chongqing 400715, |
| 推荐引用方式 GB/T 7714 | Sun, Yunxiang,Kakinen, Aleksandr,Wan, Xulin,et al. Spontaneous formation of beta-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta[J]. NANO TODAY,2021,38:-. |
| APA | Sun, Yunxiang.,Kakinen, Aleksandr.,Wan, Xulin.,Moriarty, Niamh.,Hunt, Cameron P. J..,...&Ding, Feng.(2021).Spontaneous formation of beta-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta.NANO TODAY,38,-. |
| MLA | Sun, Yunxiang,et al."Spontaneous formation of beta-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta".NANO TODAY 38(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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