TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway
文献类型：期刊论文
| 作者 | Yang, Renjun; Liu, Shuyu; Liang, Xiaoxing; Yin, Nuoya; Jiang, Linshu; Zhang, Yang; Faiola, Francesco |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-01-05 |
| 卷号 | 401页码:- |
| ISSN号 | 0304-3894 |
| 关键词 | Halogenated flame retardants Developmental hepatic toxicity Hepatic differentiation Transcriptomics analysis FGF10 |
| 英文摘要 | Halogenated flame retardants (HFRs), including Tetrabromobisphenol A (TBBPA), Tetrabromobisphenol S (TBBPS), and Tetrachlorobisphenol A (TCBPA), are widely applied in the manufacturing industry to improve fire safety and can be detected in pregnant women's serum at nanomolar levels. Thus, it is necessary to pay attention to the three HFR potential development toxicity, which has not been conclusively addressed yet. The liver is the main organ that detoxifies our body; TBBPA exposure may lead to increased liver weight in rodents. Therefore, in this study, we assessed the developmental hepatic toxicity of the three HFRs with a human embryonic stem cell hepatic differentiation-based system and transcriptomics analyses. We mostly evaluated lineage fate alterations and demonstrated the three HFRs may have common disruptive effects on hepatic differentiation, with TCBPA being significantly more potent. More specifically, the three HFRs up-regulated genes related to cell cycle and FGF10 signaling, at late stages of the hepatic differentiation. This indicates the three chemicals promoted hepatoblast proliferation likely via up-regulating the FGF10 cascade. At the same time, we also presented a powerful way to combine in vitro differentiation and in silico transcriptomic analyses, to efficiently evaluate hazardous materials' adverse effects on lineage fate decisions during early development. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45849]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Cambridge, Dept Pathol, Wellcome Trust CRUK Gurdon Inst, Cambridge CB2 1QN, England 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Beijing Agr Univ, Beijing Key Lab Dairy Cow Nutr, Beijing 102206, Peoples R China 5.Capital Med Univ, Beijing Friendship Hosp, Dept Pharm, 95 Yongan Rd, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Renjun,Liu, Shuyu,Liang, Xiaoxing,et al. TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,401:-. |
| APA | Yang, Renjun.,Liu, Shuyu.,Liang, Xiaoxing.,Yin, Nuoya.,Jiang, Linshu.,...&Faiola, Francesco.(2021).TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway.JOURNAL OF HAZARDOUS MATERIALS,401,-. |
| MLA | Yang, Renjun,et al."TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway".JOURNAL OF HAZARDOUS MATERIALS 401(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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