Tetrabromobisphenol A induces THR beta-mediated inflammation and uterine injury in mice at environmentally relevant exposure concentrations
文献类型：期刊论文
| 作者 | Zhang, Wenjuan; Li, Aijing ; Pan, Yu; Wang, Fengbang; Li, Ming; Liang, Yong; Yao, Xinglei; Song, Jinghai; Song, Maoyong; Jiang, Guibin
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-04-05 |
| 卷号 | 407页码:- |
| 关键词 | Tetrabromobisphenol A Internal exposure Inflammation Cytokines Uterine edema |
| ISSN号 | 0304-3894 |
| 英文摘要 | Tetrabromobisphenol A (TBBPA) is a widely used flame retardant, but the adverse outcomes induced by TBBPA has not been fully elucidated. In this study, TBBPA was detected in 54.9% of 102 female Chinese volunteers with an average serum concentration of 0.34 ng/mL. To investigate whether TBBPA induces adverse outcomes at environmentally relevant exposure doses, the mice were exposed to TBBPA for 14 and 28 days. The internal doses of TBBPA in mice serum were nearly the internal doses in volunteers. TBBPA significantly increased the secretion of some pro-inflammatory cytokines and suppressed immune responses in mice under such serum concentrations after 14 and 28-days exposure. Interestingly, uterine edema was observed in TBBPA-treated mice. In primary uterine cells model, the results showed TBBPA exposure suppressed THR beta expression, leading to the activation of the inflammatory PI3K/NF-kappa B signaling pathway. Our findings indicated that the uterus is the susceptible target organ of TBBPA and TBBPA exposure might increase risk of uterine cancer through deregulating inflammation pathways. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45851]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Hosp, Dept Gen Surg, Natl Ctr Gerontol, Beijing 1000730, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wenjuan,Li, Aijing,Pan, Yu,et al. Tetrabromobisphenol A induces THR beta-mediated inflammation and uterine injury in mice at environmentally relevant exposure concentrations[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,407:-. |
| APA | Zhang, Wenjuan.,Li, Aijing.,Pan, Yu.,Wang, Fengbang.,Li, Ming.,...&Jiang, Guibin.(2021).Tetrabromobisphenol A induces THR beta-mediated inflammation and uterine injury in mice at environmentally relevant exposure concentrations.JOURNAL OF HAZARDOUS MATERIALS,407,-. |
| MLA | Zhang, Wenjuan,et al."Tetrabromobisphenol A induces THR beta-mediated inflammation and uterine injury in mice at environmentally relevant exposure concentrations".JOURNAL OF HAZARDOUS MATERIALS 407(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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