Tetrabromobisphenol A: a neurotoxicant or not?
文献类型：期刊论文
| 作者 | Dong, Mengqi; Li, Yuanyuan; Zhu, Min; Qin, Zhanfen |
| 刊名 | ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 28期号:39页码:54466-54476 |
| 关键词 | Tetrabromobisphenol A Neurotoxicity Rodents Aquatic organisms Gavage |
| ISSN号 | 0944-1344 |
| 英文摘要 | Although some regulatory agencies have claimed that consumer exposures to tetrabromobisphenol A (TBBPA) are not likely to cause adverse health effects in humans or the environment, the safety of tetrabromobisphenol A (TBBPA) has been questioned. Here, we summarize the literature concerning in vivo and in vitro neurotoxicity of TBBPA over the past decades. Most laboratory rodent studies reported that gavage administration of TBBPA at doses below 1000 mg/kg/day generally exerted no or limited effects on neuropathology and locomotor behaviors, but increased anxiety and auditory impairments were observed in several studies. In fish and amphibians, waterborne exposure to TBBPA was generally reported to disrupt neurodevelopment and lead to neurobehavioral alterations. Moreover, in vitro studies support the observations that TBBPA could exert neurotoxic effects in vertebrates. Thus, we suggest that TBBPA could have adverse effects on the nervous system in vertebrates. Given rapid excretion and low availability of TBBPA in laboratory rodents following single gavage administration, we speculate that single-daily gavage could result in an underestimation of the neurotoxic effects of TBBPA in rodents. Thus, we propose to employ multiple-daily administration routes (such as dermal, inhalation, and drinking water), to further assess the neurotoxic effects of TBBPA in mammals. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45852]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Mengqi,Li, Yuanyuan,Zhu, Min,et al. Tetrabromobisphenol A: a neurotoxicant or not?[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2021,28(39):54466-54476. |
| APA | Dong, Mengqi,Li, Yuanyuan,Zhu, Min,&Qin, Zhanfen.(2021).Tetrabromobisphenol A: a neurotoxicant or not?.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,28(39),54466-54476. |
| MLA | Dong, Mengqi,et al."Tetrabromobisphenol A: a neurotoxicant or not?".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 28.39(2021):54466-54476. |
入库方式： OAI收割
来源：生态环境研究中心
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