Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice
文献类型：期刊论文
| 作者 | Wang, Yinan; Zhang, Wenjuan; Li, Aijing ; Song, Maoyong
|
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2021 |
| 卷号 | 207页码:- |
| 关键词 | Tetrachlorobisphenol A Exposure Inflammation Cytokines Uterine edema |
| ISSN号 | 0147-6513 |
| 英文摘要 | Tetrachlorobisphenol A (TCBPA) is used as flame retardant, and it has been widely detected in the environmental and human samples. TCBPA is an endocrine disrupting chemical, but its effects on the immune system remains poorly understood. Here the effects of TCBPA on immune system were studied using combined in vivo and in vitro assays. Results showed that TCBPA could suppress the immune response in BALB/c mice via reducing the ratio of CD3(+) T lymphocytes to regulatory T cells. Moreover, TCBPA exposure significantly induced the increasing secretion of four pro-inflammatory cytokines (IL-2, IL-12, IFN-gamma, and TNF-alpha) and four anti-inflammatory cyto-kines (IL-4, IL-5, IL-10, GM-CSF) in mice serum. Interestingly, uterine edema was observed in over 80% TCBPAtreated mice after 14day exposure. TCBPA was detected in 18.6% serum samples of 150 female volunteers in this study. Therefore, our findings provided evidence that TCBPA exposure may cause adverse outcomes on immune system and uterus, suggesting that environmental exposure of TCBPA, as well as its adverse effects on human health should be of concern. |
| WOS研究方向 | Environmental Sciences ; Toxicology |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45854]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Hubei, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yinan,Zhang, Wenjuan,Li, Aijing,et al. Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,207:-. |
| APA | Wang, Yinan,Zhang, Wenjuan,Li, Aijing,&Song, Maoyong.(2021).Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,207,-. |
| MLA | Wang, Yinan,et al."Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 207(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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