The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4
文献类型：期刊论文
| 作者 | Lu, Yao; Meng, Lingyi; Ma, Donghui; Cao, Huiming; Liang, Yong; Liu, Hongwei; Wang, Yawei; Jiang, Guibin
|
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2021-03-15 |
| 卷号 | 273页码:- |
| 关键词 | PFAS Cl-PFESAs Placental transfer Binding affinity Health risk |
| ISSN号 | 0269-7491 |
| 英文摘要 | Both legacy and emerging per- and polyfluoroalkyl substances (PFAS) have been found to be threats to human health. In particular, fetuses are sensitive to xenobiotics and the placenta functions as a significant barrier for environmental pollutants. The placental transfer of PFAS is closely related to their interactions with proteins. In this study, 54 human placental samples were collected to investigate the occurrence of legacy and emerging PFAS in human placenta, including perfluorinated carboxylates (PFCAs), perfluorinated sulfonates (PFSAs), chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs), and fluorotelomer sulfonates (FTSAs). Among the legacy PFAS, perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in all samples, with PFOS and PFOA being the two predominant (mean: 0.457 and 0.242 ng/g wet weight, respectively). Among the emerging PFAS, 6:2 Cl-PFESA was detected in all samples with the mean value of 0.104 ng/g wet weight, while the detect frequency (DF) of 8:2 Cl-PFESAs was only 24%. The concentration and DF of the four FTSA congeners were low in the placentas. Molecular docking calculation results showed that the binding affinities of PFAS to the human serum albumin (HSA) were increased with chain length in each category except for the PFCAs, of which the perfluoroundecanoic acid (PFUnDA) was the turning point of binding affinity to HSA. For PFSAs, their binding affinities to organic anion transporter 4 (OAT4) were increased with the chain length except for the sodium perfluoro-1-heptanesulfonate (PFHpS) and sodium perfluoro-1-nonanesulfonate (PFNS). The calculation results demonstrated that the placental transfer of PFAS is closely related to chain length. The findings in the study can help better understand the occurrence of the PFAS in the human placenta and the placental transfer mechanisms of PFAS in human beings. (C) 2021 Published by Elsevier Ltd. |
| WOS研究方向 | Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45861]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, POB 2871, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yao,Meng, Lingyi,Ma, Donghui,et al. The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4[J]. ENVIRONMENTAL POLLUTION,2021,273:-. |
| APA | Lu, Yao.,Meng, Lingyi.,Ma, Donghui.,Cao, Huiming.,Liang, Yong.,...&Jiang, Guibin.(2021).The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4.ENVIRONMENTAL POLLUTION,273,-. |
| MLA | Lu, Yao,et al."The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4".ENVIRONMENTAL POLLUTION 273(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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