Tumor-specific fluorescence activation of rhodamine isothiocyanate derivatives
文献类型：期刊论文
| 作者 | Hu, Shiqi; Jiang, Haiping; Zhu, Jianqiang; Wang, Jinqiang; Wang, Shunhao; Tang, Jianbin; Zhou, Zhuxian; Liu, Sijin; Shen, Youqing |
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2021-02-10 |
| 卷号 | 330页码:842-850 |
| 关键词 | Tumor-specific fluorescent dyes Rhodamine B isothiocyanate Hemoglobin quenchable fluorescence Tumor oxidation stress |
| ISSN号 | 0168-3659 |
| 英文摘要 | Fluorescence is routinely used for in vivo tracking and imaging of molecules and nanostructures with assuming that the fluorescence intensity is proportional to the dye concentration. Herein, we report the unique tumor-specific fluorescence character of rhodamine B isothiocyanate derivatives (RBITCs), which emits fluorescence selectively in cancerous tissues, including small metastatic tumors, but is quenched in blood and healthy tissues. A preliminary mechanism study shows that binding of the thiourea group in the RBITCs on hemoglobin quenches their fluorescence, but the oxidation of the thiourea by the elevated reactive oxygen species in tumor activates the fluorescence. Thus, the fluorescent intensity of RBITCs is associated with the microenvironment of tissues and positively correlates with the cancer stages. These findings suggest that the RBITCs are not suitable for tracking of cargos in the presence of red blood cells but may be useful for cancer imaging and early diagnosis, and probing the tumor microenvironment. |
| WOS研究方向 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45866]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Zhejiang Univ, Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou 311215, Peoples R China 3.Zhejiang Univ, Coll Chem & Biol Engn, Minist Educ & Ctr Bionanoengn, Key Lab Biomass Chem Engn, Hangzhou 310027, Peoples R China 4.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Med Oncol, Hangzhou 310003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Shiqi,Jiang, Haiping,Zhu, Jianqiang,et al. Tumor-specific fluorescence activation of rhodamine isothiocyanate derivatives[J]. JOURNAL OF CONTROLLED RELEASE,2021,330:842-850. |
| APA | Hu, Shiqi.,Jiang, Haiping.,Zhu, Jianqiang.,Wang, Jinqiang.,Wang, Shunhao.,...&Shen, Youqing.(2021).Tumor-specific fluorescence activation of rhodamine isothiocyanate derivatives.JOURNAL OF CONTROLLED RELEASE,330,842-850. |
| MLA | Hu, Shiqi,et al."Tumor-specific fluorescence activation of rhodamine isothiocyanate derivatives".JOURNAL OF CONTROLLED RELEASE 330(2021):842-850. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。