Unified Probability Distribution and Dynamics of Lead Contents in Human Erythrocytes Revealed by Single-Cell Analysis
文献类型：期刊论文
| 作者 | Liu, Nian ; Huang, Yongshun; Zhang, Huazhou; Wang, Ting; Tao, Chen; Zhang, Aiqian; Chen, Baowei; Yin, Yongguang; Song, Maoyong; Qu, Guangbo
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2021-03-16 |
| 卷号 | 55期号:6页码:3819-3826 |
| ISSN号 | 0013-936X |
| 英文摘要 | Understanding the presence and dynamics of chemical pollutants in individual cells is fundamentally important for their trafficking, fate, and toxicity in humans. The presence of molecular components (i.e., proteins and mRNA) in individual cells of higher organisms is considered a stochastic event. The characteristics of chemical pollutants, as extrinsic compounds, in subpopulation of human cells on single-cell basis have not been explored yet. Here, we demonstrated the lead (Pb) content in individual mature erythrocytes (m-erythrocytes) of Pb-intoxicated patients, and healthy subjects exhibited a unified pattern in probability distribution (gamma distribution) and dynamics, despite being highly heterogeneous. The Pb content in individual m-erythrocytes decreased with the lifetime of m-erythrocytes. Meanwhile, the distribution and dynamics were found to be highly related to the Pb content in m-erythrocytes and was independent of patients and their status. This is the first study to analyze the distribution pattern of chemical pollutants at a single-cell level in higher organisms. This study sheds light on the molecular mechanism of Pb trafficking and fate in humans and the search for an efficient strategy to improve Pb excretion during Pb treatment. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45869]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Huizhou City Occupat Dis Prevent & Control Hosp, Huizhou 516008, Guangdong, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Guangdong Prov Hosp Occupat Dis Prevent & Treatme, Dept Occupat Med, Guangzhou 510300, Guangdong, Peoples R China 5.Sun Yat Sen Univ, Sch Marine Sci, Guangdong Prov Key Lab Marine Resources & Coastal, Guangzhou 510275, Peoples R China 6.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Nian,Huang, Yongshun,Zhang, Huazhou,et al. Unified Probability Distribution and Dynamics of Lead Contents in Human Erythrocytes Revealed by Single-Cell Analysis[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2021,55(6):3819-3826. |
| APA | Liu, Nian.,Huang, Yongshun.,Zhang, Huazhou.,Wang, Ting.,Tao, Chen.,...&Jiang, Guibin.(2021).Unified Probability Distribution and Dynamics of Lead Contents in Human Erythrocytes Revealed by Single-Cell Analysis.ENVIRONMENTAL SCIENCE & TECHNOLOGY,55(6),3819-3826. |
| MLA | Liu, Nian,et al."Unified Probability Distribution and Dynamics of Lead Contents in Human Erythrocytes Revealed by Single-Cell Analysis".ENVIRONMENTAL SCIENCE & TECHNOLOGY 55.6(2021):3819-3826. |
入库方式： OAI收割
来源：生态环境研究中心
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