Use of macrophage as a Trojan horse for cancer nanotheranostics
文献类型：期刊论文
| 作者 | Qi, Yu; Yan, Xu; Xia, Tian; Liu, Sijin |
| 刊名 | MATERIALS & DESIGN
 |
| 出版日期 | 2021-01-15 |
| 卷号 | 198页码:- |
| 关键词 | Nanomaterials Macrophages Drug delivery Cancer theranostics Cancer immunology |
| ISSN号 | 0264-1275 |
| 英文摘要 | Nano-based cancer theranostics are often not as effective as expected due to the low accumulation of nanoparticles in tumors, and cell-aided strategies may represent a rescue to improve the efficacy of nanomedicines. Among the strategies, macrophages appear to be an outstanding candidate due to their wide-spread tissue presence and natural ability to take up nanoparticles carrying cargoes, and also the remarkable capability to modulate tumormicroenvironment for enhanced therapeutic efficacy and anti-tumor immunotherapy. However, there are limitations, inconsistencies, and knowledge gaps in the current stage in developing macrophage-mediated nanotherapeutics to realize its fullest potential. Thus, it demands more efforts on understanding the interplays between macrophage and nanomedicine as well as nanomedicines and tumor cells in modulating anti-cancer immunity in the tumor microenvironment. Here, we recapitulate the current progress and knowledge gaps in the macrophage-mediated nano-drug delivery system, and we also shed light on future research directions towards clinical translation. (C) 2020 Published by Elsevier Ltd. |
| WOS研究方向 | Materials Science, Multidisciplinary |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45870]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90095 USA 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Yu,Yan, Xu,Xia, Tian,et al. Use of macrophage as a Trojan horse for cancer nanotheranostics[J]. MATERIALS & DESIGN,2021,198:-. |
| APA | Qi, Yu,Yan, Xu,Xia, Tian,&Liu, Sijin.(2021).Use of macrophage as a Trojan horse for cancer nanotheranostics.MATERIALS & DESIGN,198,-. |
| MLA | Qi, Yu,et al."Use of macrophage as a Trojan horse for cancer nanotheranostics".MATERIALS & DESIGN 198(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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