Evaluation of the effects of low nanomolar bisphenol A-like compounds' levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models
文献类型：期刊论文
| 作者 | Liang, Xiaoxing; Yang, Renjun; Yin, Nuoya; Faiola, Francesco |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2021-04-05 |
| 卷号 | 407页码:- |
| ISSN号 | 0304-3894 |
| 关键词 | Human embryonic stem cells (hESCs) Embryoid bodies (EBs) Bisphenols Developmental Toxicity Stem cell toxicology |
| 英文摘要 | The widely used chemical bisphenol A (BPA) has been associated with several health effects. In recent years, many derivatives were developed to replace BPA although without thorough toxicological evaluation. Here, we employed a human embryoid body (EB)-based in vitro global differentiation and hepatic specification models, followed by RNA-seq analyses, to comprehensively study the potential developmental toxicity of six BPA replacements (BPS, BPF, BPZ, BPB, BPE, and BPAF), as compared to BPA. We found that those bisphenols may disrupt lineage commitment and lipid metabolism during early embryonic development. These effects mostly manifested via the dysregulation of HOX and APO family genes. Moreover, among the seven bisphenols analyzed, BPE seemed to have the mildest effects. |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/45874]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Xiaoxing,Yang, Renjun,Yin, Nuoya,et al. Evaluation of the effects of low nanomolar bisphenol A-like compounds' levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,407:-. |
| APA | Liang, Xiaoxing,Yang, Renjun,Yin, Nuoya,&Faiola, Francesco.(2021).Evaluation of the effects of low nanomolar bisphenol A-like compounds' levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models.JOURNAL OF HAZARDOUS MATERIALS,407,-. |
| MLA | Liang, Xiaoxing,et al."Evaluation of the effects of low nanomolar bisphenol A-like compounds' levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models".JOURNAL OF HAZARDOUS MATERIALS 407(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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