Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage
文献类型：期刊论文
| 作者 | Liu, Xuting; Wei, Wei ; Liu, Zixuan; Song, Erqun; Lou, Jianlin; Feng, Lingfang; Huang, Rongchong; Chen, Chunying; Ke, Pu Chun; Song, Yang
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| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2021-11-01 |
| 卷号 | 118期号:44页码:- |
| 关键词 | silica nanoparticle corona apolipoprotein A-I cardiovascular damage atherosclerosis |
| ISSN号 | 0027-8424 |
| 英文摘要 | The rapid development of nanotechnology has greatly benefited modern science and engineering and also led to an increased environmental exposure to nanoparticles (NPs). While recent research has established a correlation between the exposure of NPs and cardiovascular diseases, the intrinsic mechanisms of such a connection remain unclear. Inhaled NPs can penetrate the air-blood barrier from the lung to systemic circulation, thereby intruding the cardiovascular system and generating cardiotoxic effects. In this study, on-site cardiovascular damage was observed in mice upon respiratory exposure of silica nanoparticles (SiNPs), and the corresponding mechanism was investigated by focusing on the interaction of SiNPs and their encountered biomacromolecules en route. SiNPs were found to collect a significant amount of apolipoprotein A-I (Apo A-I) from the blood, in particular when the SiNPs were preadsorbed with pulmonary surfactants. While the adsorbed Apo A-I ameliorated the cytotoxic and proinflammatory effects of SiNPs, the protein was eliminated from the blood upon clearance of the NPs. However, supplementation of Apo A-I mimic peptide mitigated the atherosclerotic lesion induced by SiNPs. In addition, we found a further declined plasma Apo A-I level in clinical silicosis patients than coronary heart disease patients, suggesting clearance of SiNPs sequestered Apo A-I to compromise the corona! protein's regular biological functions. Together, this study has provided evidence that the protein corona of SiNPs acquired in the blood depletes Apo A-I, a biomarker for prediction of cardiovascular diseases, which gives rise to unexpected toxic effects of the nanoparticles. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/46823]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100053, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.[Chen, Chunying 4.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China 5.Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia 6.Chinese Acad Med Sci, Res Unit Nanosci & Technol, Beijing 100039, Peoples R China 7.Southwest Univ, Coll Pharmaceut Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China 8.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 9.Hangzhou Med Coll, Sch Publ Hlth, Hangzhou 310051, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xuting,Wei, Wei,Liu, Zixuan,et al. Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118(44):-. |
| APA | Liu, Xuting.,Wei, Wei.,Liu, Zixuan.,Song, Erqun.,Lou, Jianlin.,...&Song, Yang.(2021).Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118(44),-. |
| MLA | Liu, Xuting,et al."Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118.44(2021):-. |
入库方式： OAI收割
来源：生态环境研究中心
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