3-tert-Butyl-4-hydroxyanisole Impairs Hepatic Lipid Metabolism in Male Mice Fed with a High-Fat Diet
文献类型：期刊论文
| 作者 | Sun, Zhendong; Tang, Zhi; Yang, Xiaoxi ; Liu, Qian S.; Zhang, Jianqing; Zhou, Qunfang; Jiang, Guibin
|
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2022-03-01 |
| 卷号 | 56期号:5页码:3204-3213 |
| ISSN号 | 0013-936X |
| 关键词 | SYNTHETIC PHENOLIC ANTIOXIDANTS LIVER-DISEASE EXPOSURE HOMEOSTASIS |
| 英文摘要 | 3-tert-Butyl-4-hydroxyanisole (3-BHA), one of the widely used food antioxidants, has been found to act as a potential obesogen by promoting adipogenesis in vitro and inducing white adipose tissue development in vivo. Whether 3-BHA-induced visceral obesity was accompanied by a disruption of hepatic lipid homeostasis in mammals remained unclear. In this study, we evaluated the effect of 3-BHA on the development of nonalcoholic fatty liver disease (NAFLD) in male C57BL/6J mice. After 18 weeks of oral administration of 10 mg/kg 3-BHA, the mice fed with a high-fat diet (HFD) had higher hepatic triglyceride concentrations (0.32 mg/mg protein) and severer steatosis (1.57 for the NAFLD score) than the control ones. The in vivo hepatic lipid deposition disturbed by 3-BHA was transcriptionally regulated by the genes involved in lipid uptake, de novo lipogenesis, fatty acid oxidation, and lipid export. The in vitro studies further confirmed that 24 h of exposure to 50 mu M 3-BHA could induce intracellular oleic acid (OA) uptake and triglyceride accumulation (1.5-fold of the OA control) in HepG2 cells. Lipidomic analysis indicated the perturbation of 3-BHA in the levels of 30 lipid species related to sphingolipids, glycerophospholipids, and glycerolipids under HFD conditions. The findings herein first revealed the disruption effect of 3-BHA on hepatic lipid homeostasis, thus exacerbating the development of HFD-induced NAFLD. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47448]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Zhou, Qunfang |
| 作者单位 | 1.Shenzhen Ctr Dis Control & Prevent, Dept POPs Lab, Shenzhen 518055, Peoples R China 2.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Guangdong Med Univ, Sch Publ Hlth, Inst Environm Hlth, Dongguan Key Lab Environm Med, Dongguan 523808, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Zhendong,Tang, Zhi,Yang, Xiaoxi,et al. 3-tert-Butyl-4-hydroxyanisole Impairs Hepatic Lipid Metabolism in Male Mice Fed with a High-Fat Diet[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(5):3204-3213. |
| APA | Sun, Zhendong.,Tang, Zhi.,Yang, Xiaoxi.,Liu, Qian S..,Zhang, Jianqing.,...&Jiang, Guibin.(2022).3-tert-Butyl-4-hydroxyanisole Impairs Hepatic Lipid Metabolism in Male Mice Fed with a High-Fat Diet.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(5),3204-3213. |
| MLA | Sun, Zhendong,et al."3-tert-Butyl-4-hydroxyanisole Impairs Hepatic Lipid Metabolism in Male Mice Fed with a High-Fat Diet".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.5(2022):3204-3213. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。