Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages
文献类型：期刊论文
| 作者 | Yan, Xu; Chen, Yucai ; Ma, Li; Liu, Yongchun; Qi, Yu; Liu, Sijin
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| 刊名 | ANTIOXIDANTS
 |
| 出版日期 | 2022-04 |
| 卷号 | 11期号:4页码:754 |
| 关键词 | OXIDATIVE STRESS GRAPHENE OXIDE LUNG-FUNCTION AMBIENT POLLUTION TOXICITY EXPOSURE CELLS NANOPARTICLES POLARIZATION |
| 英文摘要 | There are still significant concerns about the detrimental effects and health risks of particulate matters (PMs) on the respiratory system. Notably, a largely overlooked knowledge gap is whether the environmental ageing process would change the physicochemical properties of PMs as well as the toxic influences of PMs on macrophages. Here, we applied ambient treatment of model PMs to mimic the real O-3-induced ageing process and investigated ageing-determined cytotoxicity profile changes of PMs towards macrophages. The consequent distinct bioreactivity and toxicity towards macrophages are largely attributed to the changes of species of surface O-functional groups. Importantly, we unveiled the specific interactions between aged PMs and macrophages due to the variant contents of the surface carboxyl group, resulting in the divergent inflammatory activations and immune balance in the lung. Collectively, this study unearths the significance of ageing in altering particle cytotoxicity, and also provides additional understandings for consecutive investigations on the adverse effects of air pollution on the respiratory system. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47463]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qi, Yu |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Beijing Univ Chem Technol, Adv Innovat Ctr Soft Matter Sci & Engn, Aerosol & Haze Lab, Beijing 100029, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Xu,Chen, Yucai,Ma, Li,et al. Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages[J]. ANTIOXIDANTS,2022,11(4):754. |
| APA | Yan, Xu,Chen, Yucai,Ma, Li,Liu, Yongchun,Qi, Yu,&Liu, Sijin.(2022).Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages.ANTIOXIDANTS,11(4),754. |
| MLA | Yan, Xu,et al."Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages".ANTIOXIDANTS 11.4(2022):754. |
入库方式： OAI收割
来源：生态环境研究中心
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