Anionic nanoplastic exposure induces endothelial leakiness
文献类型：期刊论文
| 作者 | Wei, Wei ; Li, Yuhuan; Lee, Myeongsang; Andrikopoulos, Nicholas; Lin, Sijie; Chen, Chunying; Leong, David Tai; Ding, Feng; Song, Yang; Ke, Pu Chun
|
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2022-08-13 |
| 卷号 | 13期号:1页码:4757 |
| 关键词 | VE-CADHERIN NANOPARTICLES PROTEINS DYNAMICS BETA PERMEABILITY P120-CATENIN AUTOPHAGY JUNCTIONS ENERGY |
| 英文摘要 | The global-scale production of plastics has been instrumental in advancing modern society, while the rising accumulation of plastics in landfills, oceans, and anything in between has become a major stressor on environmental sustainability, climate, and, potentially, human health. While mechanical and chemical forces of man and nature can eventually break down or recycle plastics, our understanding of the biological fingerprints of plastics, especially of nanoplastics, remains poor. Here we report on a phenomenon associated with the nanoplastic forms of anionic polystyrene and poly(methyl methacrylate), where their introduction disrupted the vascular endothelial cadherin junctions in a dose-dependent manner, as revealed by confocal fluorescence microscopy, signaling pathways, molecular dynamics simulations, as well as ex vivo and in vivo assays with animal model systems. Collectively, our results implicated nanoplastics-induced vasculature permeability as primarily biophysical-biochemical in nature, uncorrelated with cytotoxic events such as reactive oxygen species production, autophagy, and apoptosis. This uncovered route of paracellular transport has opened up vast avenues for investigating the behaviour and biological effects of nanoplastics, which may offer crucial insights for guiding innovations towards a sustainable plastics industry and environmental remediation. In this study, the authors report that anionic nanoplastics can harness the paracellular space of endothelial cells and puncture blood vasculature ex vivo and in vivo, thereby entailing new environmental and health implications. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47465]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, 381 Royal Parade, Parkville, Vic 3052, Australia 2.Clemson Univ, Dept Phys & Astron, Clemson, SC 29634 USA 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, 2 Tiansheng Rd, Chongqing 400715, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wei,Li, Yuhuan,Lee, Myeongsang,et al. Anionic nanoplastic exposure induces endothelial leakiness[J]. NATURE COMMUNICATIONS,2022,13(1):4757. |
| APA | Wei, Wei.,Li, Yuhuan.,Lee, Myeongsang.,Andrikopoulos, Nicholas.,Lin, Sijie.,...&Ke, Pu Chun.(2022).Anionic nanoplastic exposure induces endothelial leakiness.NATURE COMMUNICATIONS,13(1),4757. |
| MLA | Wei, Wei,et al."Anionic nanoplastic exposure induces endothelial leakiness".NATURE COMMUNICATIONS 13.1(2022):4757. |
入库方式： OAI收割
来源：生态环境研究中心
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