Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size
文献类型：期刊论文
| 作者 | He, Qinghao ; Lu, Jing; Liu, Nian; Lu, Wenqing; Li, Yu; Shang, Chao; Li, Xiao; Hu, Ligang; Jiang, Guibin
|
| 刊名 | NANOMATERIALS
 |
| 出版日期 | 2022-03 |
| 卷号 | 12期号:6页码:990 |
| 关键词 | VIRUS INHIBITION INFECTION PEPTIDES |
| 英文摘要 | Coronavirus disease 2019 (COVID-19) has spread rapidly and led to over 5 million deaths to date globally. Due to the successively emerging mutant strains, therapeutics and prevention against the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are urgently needed. Prevention of SARS-CoV-2 infection in public and hospital areas is essential to reduce the frequency of infections. Silver nanoparticles (AgNPs) with virucidal effects have been reported. Therefore, we investigated the virucidal activity and safety of ten types of AgNPs with different surface modifications and particle sizes, in cells exposed to SARS-CoV-2 in vitro. The AgNPs could effectively inhibit the activity of SARS-CoV-2, and different surface modifications and particle sizes conferred different virucidal effects, of which 50-nm BPEI showed the strongest antiviral effect. We concluded that the efficacy of each type of AgNP type was positively correlated with the corresponding potential difference (R-2 = 0.82). These in vitro experimental data provide scientific support for the development of therapeutics against COVID-19, as well as a research basis for the development of broad-spectrum virucides. Given the increasing acquired resistance of pathogens against conventional chemical and antibody-based drugs, AgNPs may well be a possible solution for cutting off the route of transmission, either as an external material or a potential medicine. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47466]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Hu, Ligang |
| 作者单位 | 1.Hebei Univ, Sch Life Sci, Baoding 071002, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China 4.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 5.Jianghan Univ, Sch Environm & Hlth, Wuhan 430056, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Qinghao,Lu, Jing,Liu, Nian,et al. Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size[J]. NANOMATERIALS,2022,12(6):990. |
| APA | He, Qinghao.,Lu, Jing.,Liu, Nian.,Lu, Wenqing.,Li, Yu.,...&Jiang, Guibin.(2022).Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size.NANOMATERIALS,12(6),990. |
| MLA | He, Qinghao,et al."Antiviral Properties of Silver Nanoparticles against SARS-CoV-2: Effects of Surface Coating and Particle Size".NANOMATERIALS 12.6(2022):990. |
入库方式： OAI收割
来源：生态环境研究中心
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