Associations between Novel and Legacy Per- and Polyfluoroalkyl Substances in Human Serum and Thyroid Cancer: A Case and Healthy Population in Shandong Province, East China
文献类型：期刊论文
| 作者 | Liu, Mei ; Zhang, Gaoxin; Meng, Lingling; Han, Xu; Li, Yingming; Shi, Yali; Li, An; Turyk, Mary E.; Zhang, Qinghua; Jiang, Guibin
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2022-05-17 |
| 卷号 | 56期号:10页码:6144-6151 |
| 关键词 | PERFLUOROALKYL SUBSTANCES PREGNANT-WOMEN EXPOSURE ACIDS PARAMETERS HORMONE PERFLUOROOCTANOATE ELIMINATION COMMUNITY CHILDREN |
| ISSN号 | 0013-936X |
| 英文摘要 | Per- and polytluoroalkyl substances (PFASs) are widely detected in the environment and may cause adverse human health effects after exposure. Studies on the effect of PFASs on some health end points, including cancer, are still limited and show inconsistent results. In this research, 319 participants were recruited from Shandong Province, East China, consisting of patients with thyroid cancer and healthy controls. Seven novel and legacy PFASs were frequently detected (detection rate > 75%) in the serum samples of the participants. The concentrations of perfluorooctanoic acid (PFOA) were the highest in the case and control groups. Males showed significantly higher concentrations of PFASs than females. Exposure to PFASs was inversely associated with the risk of thyroid cancer. In the control group, we identified significant positive associations between PFASs and free thyroxine (FT4) as well as between PFOA and thyroid stimulating hormone (TSH) in females. A significant negative association between perfluorononanoic acid (PFNA) and triiodothyronine (T3) was observed in males. Our results suggest that exposure to certain PFASs could interfere with thyroid function. To our knowledge, this is the first case-control study demonstrating associations between novel and legacy PFASs in human and thyroid cancer. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47474]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Li, Yingming |
| 作者单位 | 1.Sinopec, Res Inst Petr Proc, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China 5.Shandong First Med Univ, Hosp 1, Shandong Prov Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Mei,Zhang, Gaoxin,Meng, Lingling,et al. Associations between Novel and Legacy Per- and Polyfluoroalkyl Substances in Human Serum and Thyroid Cancer: A Case and Healthy Population in Shandong Province, East China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(10):6144-6151. |
| APA | Liu, Mei.,Zhang, Gaoxin.,Meng, Lingling.,Han, Xu.,Li, Yingming.,...&Jiang, Guibin.(2022).Associations between Novel and Legacy Per- and Polyfluoroalkyl Substances in Human Serum and Thyroid Cancer: A Case and Healthy Population in Shandong Province, East China.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(10),6144-6151. |
| MLA | Liu, Mei,et al."Associations between Novel and Legacy Per- and Polyfluoroalkyl Substances in Human Serum and Thyroid Cancer: A Case and Healthy Population in Shandong Province, East China".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.10(2022):6144-6151. |
入库方式： OAI收割
来源：生态环境研究中心
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