Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium
文献类型：期刊论文
| 作者 | Zhu, Jianqiang; Liu, Leyi; Ma, Juan ; Fu, Qingfeng; Zheng, Zhiwen; Du, E.; Xu, Yong; Zhang, Zhihong
|
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2022-08-01 |
| 卷号 | 306期号:0页码:119421 |
| ISSN号 | 0269-7491 |
| 关键词 | OXIDATIVE-STRESS NANOPARTICLES CYTOTOXICITY MEMBRANE TOXICITY DESIGN CELLS |
| 英文摘要 | Graphene oxide (GO) has been widely studied and applied in numerous industrial fields and biomedical fields for its excellent physical and chemical properties. Along with the production and applications of GO persist increasing, the environmental health and safety risk (EHS) of GO has been widely studied. However, previous studies almost focused on the biotoxicity of pristine GO under a relatively high exposure dose, without considering its transformation process within environmental and biological mediums. Meanwhile, its secondary toxicity or synergistic effects have not been taken seriously. Here, two different kinds of artificial lung fluids were adopted to incubate pristine GO to mimic the biotransformation process of GO in the lung fluids. And, we explored that biotransformation within the artificial lung fluids could significantly change the physicochemical properties of GO and could enhance its biotoxicity. To reveal the synergistic effects of GO and toxic metal ions, we uncovered that GO could enhance the intracellular content of metal ions by inhibiting the efflux function of ATP binding cassette (ABC) transporters which are distributed on the cellular membrane, and artificial lung fluids incubation of GO could enhance this synergistic effect. Finally, toxic metal ions induced a series of toxic reactions through oxidative stress response and promoted cell death. Moreover, consistent with the results of in vitro experiments, the lungs of mice exposed to GOs combined with Cd exhibited significant inflammation and oxidative stress compared with Cd treatment alone, and it was more remarkable within the mice which were treated with bio-transformed GOs. In summary, this study explored the impact and mechanism of biotransformation of GO in the lung fluids on the synergistic and secondary effects between GO and metal ions. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47480]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Zhang, Zhihong |
| 作者单位 | 1.Second Hosp Tianjin Med Univ, Tianjin Inst Urol, Dept Urol, Tianjin 300211, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Jianqiang,Liu, Leyi,Ma, Juan,et al. Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium[J]. ENVIRONMENTAL POLLUTION,2022,306(0):119421. |
| APA | Zhu, Jianqiang.,Liu, Leyi.,Ma, Juan.,Fu, Qingfeng.,Zheng, Zhiwen.,...&Zhang, Zhihong.(2022).Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.ENVIRONMENTAL POLLUTION,306(0),119421. |
| MLA | Zhu, Jianqiang,et al."Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium".ENVIRONMENTAL POLLUTION 306.0(2022):119421. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。