Bisphenol chemicals disturb intestinal homeostasis via Notch/Wnt signaling and induce mucosal barrier dysregulation and inflammation
文献类型：期刊论文
| 作者 | Zhu, Min; Wei, Rongguo; Li, Yuanyuan ; Li, Jinbo; Dong, Mengqi; Chen, Xuanyue; Lv, Lin; Qin, Zhanfen
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2022-07-01 |
| 卷号 | 828期号:0页码:154444 |
| 关键词 | STEM-CELLS PERINATAL EXPOSURE A ALTERS ANALOGS WATER DIFFERENTIATION RESPONSES HEALTH BPF WNT |
| ISSN号 | 0048-9697 |
| 英文摘要 | Emerging evidence has shown that bisphenol A (BPA) can exert adverse effects on intestinal barrier in rodents, but lit-tle is known about its underlying mechanisms. We previously found BPA and its substitute bisphenol F (BPF) disrupted Notch signaling and altered intestinal histological structures in Xenopus laevis tadpoles. The present study aimed to de-termine whether BPA and BPF could affect intestinal homeostasis via Notch/Wnt signaling and induce intestinal bar-rier dysregulation in adult mammals, given the fundamental roles of the two conserved signaling pathways in intestinal homeostasis and regulation of intestinal barrier. We found that following 7-day administration with BPA or BPF through drinking water at the reference dose of 50 mu g/kg/d and no observed adverse effect level of 5 mg/kg/d (NOAEL) of BPA, adult male mice displayed no alterations at histological and cellular levels in colons, but high dose of both BPA and BPF downregulated the expression of Notch-and Wnt-related genes as well as key genes responsible for intestinal homeostasis. When administration was extended to 14 days, all treatments significantly sup-pressed the expression of all tested Notch-and Wnt-related genes; correspondingly, administrated colons exhibited downregulated expression of key genes responsible for intestinal homeostasis and reduced cell proliferation in crypts. Importantly, all treatments suppressed secretory cell differentiation, reduced mucin protein levels and downregulated expression of tight junction markers, implicating mucosal barrier dysregulation. Furthermore, inflammatory cell infiltration and upregulated expression of inflammatory cytokine genes in colons, coupled with increased serum inflammatory cytokine levels, were observed in all treatments. All results show that both BPA and BPF at the reference dose disrupted Notch/Wnt signaling and intestinal homeostasis, thereby leading to mucosal barrier dysregulation and intestinal inflammation in mice. This is the first study revealing the adverse influences of BPF on mammal intestines and underlying mechanisms for bisphenol-caused intestinal injury. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47482]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qin, Zhanfen |
| 作者单位 | 1.Jiangsu Prov Acad Environm Sci, Jiangsu Prov Key Lab Environm Engn, Nanjing 210036, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Guangxi Med Univ, Affiliated Hosp 5, Dept Clin Lab, Nanning 530016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Min,Wei, Rongguo,Li, Yuanyuan,et al. Bisphenol chemicals disturb intestinal homeostasis via Notch/Wnt signaling and induce mucosal barrier dysregulation and inflammation[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,828(0):154444. |
| APA | Zhu, Min.,Wei, Rongguo.,Li, Yuanyuan.,Li, Jinbo.,Dong, Mengqi.,...&Qin, Zhanfen.(2022).Bisphenol chemicals disturb intestinal homeostasis via Notch/Wnt signaling and induce mucosal barrier dysregulation and inflammation.SCIENCE OF THE TOTAL ENVIRONMENT,828(0),154444. |
| MLA | Zhu, Min,et al."Bisphenol chemicals disturb intestinal homeostasis via Notch/Wnt signaling and induce mucosal barrier dysregulation and inflammation".SCIENCE OF THE TOTAL ENVIRONMENT 828.0(2022):154444. |
入库方式： OAI收割
来源：生态环境研究中心
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