Dechloranes exhibit binding potency and activity to thyroid hormone receptors
文献类型：期刊论文
| 作者 | Zhu, Jianqiao; Zhao, Lixia ; Guo, Lianghong
|
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2022-02 |
| 卷号 | 112期号:0页码:16-24 |
| 关键词 | CHLORINATED FLAME-RETARDANT DIPHENYL ETHERS PBDES ISOMER PROFILES DECHLORINATED ANALOGS MATERNAL SERUM PLUS BIOACCUMULATION EXPOSURE RESIDENTS BEHAVIOR |
| ISSN号 | 1001-0742 |
| 英文摘要 | Dechloranes are a group of halogenated flame retardants with a basic bicyclo[2.2.1]heptene, including Dechlorane Plus (DP), Dechlorane 602 (Dec 602), Dechlorane 603 (Dec 603) and Dechlorane 604 (Dec 604). A few epidemiological investigations and animal experiments have shown that DP exhibited thyroid-interfering effects. In the present study, we investigated whether DP and three other dechloranes could interfere the thyroid function through thyroid hormone receptors (TRs, TR alpha and TR ,6) signaling pathways. The binding affinities of the four dechloranes to the two TRs were determined by fluorescence competitive binding assay. It was found that all the four dechloranes could bind with the two TRs. The relative potency (RP) values ranged from nd (not detectable) to 0.0667. Between the two TRs, dechloranes were more inclined to bind with TR ,6, which implies that the thyroid interference effect of dechloranes may have selectivity in different tissues and organs. TRs-mediated luciferase reporter gene assay and T-screen assay showed that all the four dechloranes exhibited antagonistic activity to TRs in the cells. Taken together, our results demonstrated that dechloranes might interfere with thyroid function by binding with TRs and acting as TR antagonists. The health risk of highly exposed human populations should be of serious concern because of the high hazard quotient calculated from our cell assay results. (c) 2021 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47501]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Guo, Lianghong |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.China Jiliang Univ, Inst Environm & Hlth Sci, Hangzhou 310018, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Jianqiao,Zhao, Lixia,Guo, Lianghong. Dechloranes exhibit binding potency and activity to thyroid hormone receptors[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2022,112(0):16-24. |
| APA | Zhu, Jianqiao,Zhao, Lixia,&Guo, Lianghong.(2022).Dechloranes exhibit binding potency and activity to thyroid hormone receptors.JOURNAL OF ENVIRONMENTAL SCIENCES,112(0),16-24. |
| MLA | Zhu, Jianqiao,et al."Dechloranes exhibit binding potency and activity to thyroid hormone receptors".JOURNAL OF ENVIRONMENTAL SCIENCES 112.0(2022):16-24. |
入库方式： OAI收割
来源：生态环境研究中心
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