Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human
文献类型：期刊论文
| 作者 | Liu, Wei ; Wu, Yue; Zhang, Na; Liu, Sijin; Zhou, Li
|
| 刊名 | DISEASE MARKERS
 |
| 出版日期 | 2022-08-22 |
| 卷号 | 2022期号:0页码:1664474 |
| ISSN号 | 0278-0240 |
| 关键词 | HEPCIDIN CONCENTRATIONS DEFICIENCY HOMEOSTASIS PREGNANCY RISK POSTPARTUM ANEMIA WOMEN |
| 英文摘要 | Background. Increasing evidence reveals that iron deficiency during pregnancy causes adverse pregnancy outcomes. Thus far, the mechanisms underlying iron deficiency-associated preterm birth are mostly limited to animal studies. Whether the suggested mechanisms exist in human requires further investigation. The goal of this study was to characterize the iron metabolism in both the maternal side and fetal side in pregnant women with preterm birth. Methods. Serum and placenta samples were collected from 42 pregnant women divided into four groups according to the gestational week. Indicators of iron metabolism, including serum iron, serum hepcidin, placental tissue iron, ferroportin (FPN), transferrin receptor 1 (TfR1), and ferritin, were surveyed using enzyme-linked immunosorbent assays (Elisa), Western blots, and real-time quantitative polymerase chain reactions (qRT-PCR). Results. Significant reduction of maternal serum iron was observed in women with preterm birth relative to those with full-term birth, indicative of worsen iron deficiency in those mothers with preterm birth. Meanwhile, the maternal hepcidin levels were notably diminished in women with preterm birth, whereas the fetal hepcidin levels were comparable between the two groups. Moreover, the placental iron stores were remarkably reduced in the preterm group, associated with reduced concentration of TfR1 and increased FPN concentration relative to the normal controls. In other words, the ratio of placental FPN mass to TfR1 mass (PIDI index) was strikingly increased in the preterm group. Conclusions. Dysregulated iron homeostasis in both the maternal and fetal sides was implicated in preterm births, and disordered regulations in maintaining the placental iron equilibrium were also presumed to account for the compromised fetal iron supply. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47509]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Zhou, Li |
| 作者单位 | 1.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China 2.Beijing Maternal & Child Hlth Care Hosp, Beijing 100026, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Wei,Wu, Yue,Zhang, Na,et al. Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human[J]. DISEASE MARKERS,2022,2022(0):1664474. |
| APA | Liu, Wei,Wu, Yue,Zhang, Na,Liu, Sijin,&Zhou, Li.(2022).Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human.DISEASE MARKERS,2022(0),1664474. |
| MLA | Liu, Wei,et al."Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human".DISEASE MARKERS 2022.0(2022):1664474. |
入库方式： OAI收割
来源：生态环境研究中心
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