Double-edge sword roles of iron in driving energy production versus instigating ferroptosis
文献类型：期刊论文
| 作者 | Zhang, Shuping ; Xin, Wei; Anderson, Gregory J.; Li, Ruibin; Gao, Ling; Chen, Shuguang; Zhao, Jiajun; Liu, Sijin
|
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2022-01-10 |
| 卷号 | 13期号:1页码:40 |
| ISSN号 | 2041-4889 |
| 关键词 | HEPATIC GLUCOSE-PRODUCTION FATTY-ACID OXIDATION CELL-DEATH PARKINSONS-DISEASE DIABETES-MELLITUS METABOLISM TUMOR MITOCHONDRIA HOMEOSTASIS DEFICIENCY |
| 英文摘要 | Iron is vital for many physiological functions, including energy production, and dysregulated iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized form of regulated cell death that is characterized by iron dependency and lipid peroxidation, and this process has been reported to be involved in multiple diseases. The mechanisms underlying ferroptosis are complex, and involve both well-described pathways (including the iron-induced Fenton reaction, impaired antioxidant capacity, and mitochondrial dysfunction) and novel interactions linked to cellular energy production. In this review, we examine the contribution of iron to diverse metabolic activities and their relationship to ferroptosis. There is an emphasis on the role of iron in driving energy production and its link to ferroptosis under both physiological and pathological conditions. In conclusion, excess reactive oxygen species production driven by disordered iron metabolism, which induces Fenton reaction and/or impairs mitochondrial function and energy metabolism, is a key inducer of ferroptosis. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47512]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan 250031, Shandong, Peoples R China 2.Shandong First Med Univ & Shandong Acad Med Sci, Med Sci & Technol Innovat Ctr, Jinan 250117, Shandong, Peoples R China 3.QIMR Berghofer Med Res Inst, Iron Metab Lab, Brisbane, Qld 4006, Australia 4.Soochow Univ, Sch Radiol & Interdisciplinary Sci, Suzhou 215123, Jiangsu, Peoples R China 5.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Beijin |
| 推荐引用方式 GB/T 7714 | Zhang, Shuping,Xin, Wei,Anderson, Gregory J.,et al. Double-edge sword roles of iron in driving energy production versus instigating ferroptosis[J]. CELL DEATH & DISEASE,2022,13(1):40. |
| APA | Zhang, Shuping.,Xin, Wei.,Anderson, Gregory J..,Li, Ruibin.,Gao, Ling.,...&Liu, Sijin.(2022).Double-edge sword roles of iron in driving energy production versus instigating ferroptosis.CELL DEATH & DISEASE,13(1),40. |
| MLA | Zhang, Shuping,et al."Double-edge sword roles of iron in driving energy production versus instigating ferroptosis".CELL DEATH & DISEASE 13.1(2022):40. |
入库方式： OAI收割
来源：生态环境研究中心
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