Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies
文献类型：期刊论文
| 作者 | Cao, Huiming; Zhou, Zhen; Hu, Zhe; Wei, Cuiyun; Li, Jie; Wang, Ling; Liu, Guangliang; Zhang, Jie ; Wang, Yawei; Wang, Thanh
|
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2022-03-01 |
| 卷号 | 56期号:5页码:3214-3224 |
| ISSN号 | 0013-936X |
| 关键词 | PERFLUOROOCTANE SULFONATE PFOS PHARMACOKINETIC PBPK MODEL PERFLUORINATED ALKYL ACIDS BOVINE SERUM-ALBUMIN PERFLUOROALKYL ACIDS MOLECULAR DOCKING BINDING-AFFINITY TANGXUN LAKE BILE-ACIDS ELIMINATION |
| 英文摘要 | The pharmacokinetic characteristics of per- and polyfluoroalkyl substances (PFAS) affect their distribution and bioaccumulation in biological systems. The enterohepatic circulation leads to reabsorption of certain chemicals from bile back into blood and the liver and thus influences their elimination, yet its influence on PFAS bioaccumulation remains unclear. We explored the role of enterohepatic circulation in PFAS bioaccumulation by examining tissue distribution of various PFAS in wild fish and a rat model. Computational models were used to determine the reabsorbed fractions of PFAS by calculating binding affinities of PFAS for key transporter proteins of enterohepatic circulation. The results indicated that higher concentrations were observed in blood, the liver, and bile compared to other tissues for some PFAS in fish. Furthermore, exposure to a PFAS mixture on the rat model showed that the reabsorption phenomenon appeared during 8-12 h for most long-chain PFAS. Molecular docking calculations suggest that PFAS can bind to key transporter proteins via electrostatic and hydrophobic interactions. Further regression analysis adds support to the hypothesis that binding affinity of the apical sodium-dependent bile acid transporter is the most important variable to predict the human half-lives of PFAS. This study demonstrated the critical role of enterohepatic circulation in reabsorption, distribution, and accumulation of PFAS. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47514]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Liang, Yong |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Peoples R China 3.Huazhong Agr Univ, Coll Resources & Environm, Wuhan 430070, Peoples R China 4.Orebro Univ, MTM Res Ctr, Sch Sci & Technol, S-70182 Orebro, Sweden 5.Jianghan Univ, Key Lab Optoelect Chem Mat & Devices, Minist Educ, Wuhan 430056, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Huiming,Zhou, Zhen,Hu, Zhe,et al. Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(5):3214-3224. |
| APA | Cao, Huiming.,Zhou, Zhen.,Hu, Zhe.,Wei, Cuiyun.,Li, Jie.,...&Liang, Yong.(2022).Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(5),3214-3224. |
| MLA | Cao, Huiming,et al."Effect of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.5(2022):3214-3224. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。