Effect-Directed Analysis Based on the Reduced Human Transcriptome (RHT) to Identify Organic Contaminants in Source and Tap Waters along the Yangtze River
文献类型：期刊论文
| 作者 | Guo, Jing; Shen, Yanhong; Zhang, Xiaowei; Lin, Die; Xia, Pu; Song, Maoyong ; Yan, Lu; Zhong, Wenjun; Gou, Xiao; Wang, Chang
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2022-05-26 |
| 卷号 | 56期号:12页码:7840-7852 |
| 关键词 | INDUCED REPRODUCTIVE TOXICITY DRINKING-WATER SURFACE WATERS PHTHALATE-ESTERS RISK-ASSESSMENT WASTE-WATER LIPID-PEROXIDATION TREATMENT-PLANT MALE-RAT EXPOSURE |
| ISSN号 | 0013-936X |
| 英文摘要 | Since a large number of contaminants are detected in source waters (SWs) and tap waters (TWs), it is important to perform a comprehensive effect evaluation and key contributor identification. A reduced human transcriptome (RHT)-based effect-directed analysis, which consisted of a concentration-dependent RHT to reveal the comprehensive effects and noteworthy pathways and systematic identification of key contributors based on the interactions between compounds and pathway effects, was developed and applied to typical SWs and TWs along the Yangtze River. By RHT, 42% more differentially expressed genes and 33% more pathways were identified in the middle and lower reaches, indicating heavier pollution. Hormone and immune pathways were prioritized based on the detection frequency, sensitivity, and removal efficiency, among which the estrogen receptor pathway was the most noteworthy. Consistent with RHT, estrogenic effects were widespread along the Yangtze River based on in vitro evaluations. Furthermore, 38 of 100 targets, 39 pathway-related suspects, and 16 estrogenic nontargets were systematically identified. Among them, diethylstilbestrol was the dominant contributor, with the estradiol equivalent (EEQ) significantly correlated with EEQ(water). In addition, zearalenone and niclosamide explained up to 54% of the EEQ(water). The RHT-based EDA method could support the effect evaluation, contributor identification, and risk management of micropolluted waters. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47516]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Shi, Wei |
| 作者单位 | 1.Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China 2.Suzhou Ind Pk, Environm Monitoring Stn, Suzhou 215027, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Peoples R China 5.Jiangsu Prov Ecol & Environm Protect Key Lab Chem, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jing,Shen, Yanhong,Zhang, Xiaowei,et al. Effect-Directed Analysis Based on the Reduced Human Transcriptome (RHT) to Identify Organic Contaminants in Source and Tap Waters along the Yangtze River[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(12):7840-7852. |
| APA | Guo, Jing.,Shen, Yanhong.,Zhang, Xiaowei.,Lin, Die.,Xia, Pu.,...&Shi, Wei.(2022).Effect-Directed Analysis Based on the Reduced Human Transcriptome (RHT) to Identify Organic Contaminants in Source and Tap Waters along the Yangtze River.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(12),7840-7852. |
| MLA | Guo, Jing,et al."Effect-Directed Analysis Based on the Reduced Human Transcriptome (RHT) to Identify Organic Contaminants in Source and Tap Waters along the Yangtze River".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.12(2022):7840-7852. |
入库方式： OAI收割
来源：生态环境研究中心
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