Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood
文献类型：期刊论文
| 作者 | Li, Yuanyuan ; Xiong, Yiming; Lv, Lin; Li, Xinghong; Qin, Zhanfen
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| 刊名 | ARCHIVES OF TOXICOLOGY
 |
| 出版日期 | 2022-09-15 |
| 期号 | 0页码:1-11 |
| 关键词 | MANUFACTURING PLANT EXPOSURE ESTROGEN DIETHYLSTILBESTROL ANALOGS RATS EXPRESSION PROTEIN HEALTH |
| ISSN号 | 0340-5761 |
| 英文摘要 | Despite growing concern about adverse effects of bisphenol AF (BPAF) due to its endocrine disrupting properties, there is a lack of toxicity data from low-dose studies and direct evidence linking its adverse effects to endocrine disrupting properties. Here, we investigated the effects of gestational and postnatal exposure to BPAF through drinking water (0.15-15 mu g/mL, equivalent to the daily intake of similar to 50 and 5 mg/kg/day) on testis development in mice. We found that like mestranol, 5 mg/kg/day BPAF resulted in remarkable decreases in multiple male reproductive parameters in adulthood, such as the sperm number and serum testosterone level. Notably, 50 pg/kg/day BPAF also caused significant decreases in anogenital distance (AGD), the luteinizing hormone level and spermatocyte number, along with declining trends in sperm number and the serum levels of testosterone and follicle-stimulating hormone. In line with the adverse outcomes observed in adulthood, on postnatal day (PND) 9, we also observed BPAF-caused dose-dependent alterations, including reduced AGD, seminiferous tubule area and numbers of total germ cells, spermatocytes and Leydig cells, coupled with down-regulated expression of male-biased genes in testes. Even when exposure to 5 mg/kg/day BPAF as well as MES was initiated from PND 0, similar alterations in male reproductive parameters were also found on PND 9, along with a decrease in the GnRH content in the hypothalamus; moreover, testicular alterations and the reduction in AGD were partly antagonized by the estrogen receptor (ER) antagonist ICI 182,780, but the reduction of GnRH production was not done, showing that the effects of BPAF on testis development may be partially mediated by ER signaling. In conclusion, all the findings demonstrate that low-dose BPAF can partly disrupt mammal testis development and cause adverse testicular outcomes in adulthood, indicating a potential reproductive risk to mammals including humans. Importantly, our finding that developmental alterations elicited by BPAF have been detectable on PND 9 provides important motivation for the development of effective methods for early detection of adverse effects of estrogenic chemicals on testis development. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47518]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qin, Zhanfen |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuanyuan,Xiong, Yiming,Lv, Lin,et al. Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood[J]. ARCHIVES OF TOXICOLOGY,2022(0):1-11. |
| APA | Li, Yuanyuan,Xiong, Yiming,Lv, Lin,Li, Xinghong,&Qin, Zhanfen.(2022).Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood.ARCHIVES OF TOXICOLOGY(0),1-11. |
| MLA | Li, Yuanyuan,et al."Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood".ARCHIVES OF TOXICOLOGY .0(2022):1-11. |
入库方式： OAI收割
来源：生态环境研究中心
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