Effects of perinatal TCDD exposure on colonic microbiota and metabolism in offspring and mother mice
文献类型：期刊论文
| 作者 | Li, Jiao; Li, Yunping; Sha, Rui ; Zheng, Liping; Xu, Li; Xie, Heidi Qunhui; Zhao, Bin
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2022-08-01 |
| 卷号 | 832期号:0页码:154762 |
| ISSN号 | 0048-9697 |
| 关键词 | GUT MICROBIOME TRYPTOPHAN DIOXIN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN SUSCEPTIBILITY CATABOLISM EXPRESSION POLLUTANTS SEROTONIN MOUSE |
| 英文摘要 | Emerging evidence supports that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) impacts the gut microbiota and metabolic pathways. TCDD can be transmitted from mother to child; thus, we hypothesize that maternal exposure to TCDD may affect the gut microbiota in mothers and offspring. To acquire in vivo evidence supporting this hypothesis, female C57BL/6 mice were administered with TCDD (0.1 and 10 mu g/kg body weight (bw)) during pregnancy and lactation periods, and then changes of colonic microbiota in offspring and mothers were evaluated. High throughput sequencing of the V4 regions of the 16S rRNA gene was performed. The composition and structure of the colonic microbiota in offspring and mothers were significantly influenced by 10 mu g/kg bw TCDD as demonstrated by upregulation of harmful bacteria and downregulation of beneficial bacteria. Paradoxically, pathogenic bacteria and opportunistic pathogens were conversely decreased in the offspring of the low-dose TCDD treatment group. Tryptophan (Trp) metabolism exhibited a noticeable change caused by the alteration of colonic microbiota in offspring after maternal exposure to 10 mu g/kg bw TCDD, which showed a linear dependence, demonstrating that pathogens or opportunistic pathogens may accelerate the dysbiosis of Trp metabolism. Trp metabolism dysregulation caused by the changed colonic microbiota may subsequently impact other intestinal segments or even living organisms. Our study provides new evidence indicating a potential influence of early TCDD exposure on the colonic microbiota and metabolism. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47519]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Zhao, Bin |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 4.Nanjing Inst Environm Sci, Minist Ecol & Environm Peoples Republ China, Nanjing 210042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jiao,Li, Yunping,Sha, Rui,et al. Effects of perinatal TCDD exposure on colonic microbiota and metabolism in offspring and mother mice[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,832(0):154762. |
| APA | Li, Jiao.,Li, Yunping.,Sha, Rui.,Zheng, Liping.,Xu, Li.,...&Zhao, Bin.(2022).Effects of perinatal TCDD exposure on colonic microbiota and metabolism in offspring and mother mice.SCIENCE OF THE TOTAL ENVIRONMENT,832(0),154762. |
| MLA | Li, Jiao,et al."Effects of perinatal TCDD exposure on colonic microbiota and metabolism in offspring and mother mice".SCIENCE OF THE TOTAL ENVIRONMENT 832.0(2022):154762. |
入库方式： OAI收割
来源：生态环境研究中心
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