Effects of polyethylene microplastics on cell membranes: A combined study of experiments and molecular dynamics simulations
文献类型：期刊论文
| 作者 | Wang, Weilin; Zhang, Jinlong; Qiu, Zhiqiang; Cui, Zeyang; Li, Ningqi; Li, Xin; Wang, Yawei; Zhang, Haixia; Zhao, Chunyan |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2022-05-05 |
| 卷号 | 429期号:0页码:128323 |
| 关键词 | POLYSTYRENE MICROPLASTICS OXIDATIVE STRESS NANOPARTICLES TOXICITY INSIGHTS BILAYER |
| ISSN号 | 0304-3894 |
| 英文摘要 | Microplastics (MPs), widely distributed within the environment, can be ingested by humans easily and cause various biological reactions such as oxidative stress, immune response and membrane damage, ultimately rep-resenting a threat to health. Cell membranes work as first barrier for MPs entering the cell and playing biological effects. For now, the researches on interactions of MPs on cell membranes lack an in-depth and effective theo-retical model to understand molecular details and physicochemical behaviors. In present study, observations of calcein leakage established polyethylene plastic nanoparticles (PE PNPs), especially of high concentrations, harming cell membrane integrity. SYTOX green and lactate dehydrogenase (LDH) assays supported the evidence that the exposure of cells to PE PNPs caused significant cell membrane damage in dose-response. Molecular dynamics (MD) simulations were further applied to determine the effects of PE on the properties of dipalmitoyl phosphatidylcholine (DPPC) bilayer. PE permeated into lipid membranes easily resulting in significant variations in DPPC bilayer with lower density, fluidity changes and membrane thickening. Besides, PE aggregates bound were more likely to cause pore formation and serious damage to the DPPC bilayer. The interaction mechanisms between MPS and cell membrane were explored which provided valuable insights into membrane effect of MPs. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47520]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Zhao, Chunyan |
| 作者单位 | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 4.Henan Univ Sci & Technol, Luoyang 471023, Peoples R China 5.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Weilin,Zhang, Jinlong,Qiu, Zhiqiang,et al. Effects of polyethylene microplastics on cell membranes: A combined study of experiments and molecular dynamics simulations[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,429(0):128323. |
| APA | Wang, Weilin.,Zhang, Jinlong.,Qiu, Zhiqiang.,Cui, Zeyang.,Li, Ningqi.,...&Zhao, Chunyan.(2022).Effects of polyethylene microplastics on cell membranes: A combined study of experiments and molecular dynamics simulations.JOURNAL OF HAZARDOUS MATERIALS,429(0),128323. |
| MLA | Wang, Weilin,et al."Effects of polyethylene microplastics on cell membranes: A combined study of experiments and molecular dynamics simulations".JOURNAL OF HAZARDOUS MATERIALS 429.0(2022):128323. |
入库方式： OAI收割
来源：生态环境研究中心
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