Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events
文献类型：期刊论文
| 作者 | Li, Yuanyuan ; Dong, Mengqi; Xiong, Yiming; Chang, Qing; Chen, Xuanyue; Fu, Xufeng; Li, Xinghong; Qin, Zhanfen
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| 刊名 | ARCHIVES OF TOXICOLOGY
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| 出版日期 | 2022-06 |
| 卷号 | 96期号:6页码:1881-1892 |
| 关键词 | SERTOLI-CELL TBBPA EXPRESSION PATHWAY NOTCH MILK FATE GERM |
| ISSN号 | 0340-5761 |
| 英文摘要 | Whether or not tetrabromobisphenol A (TBBPA) has reproductive developmental toxicity remains controversial. Here, we evaluated the effects of postnatal TBBPA exposure of dams (before weaning) and pups through drinking water (15, 150, 1500 ng/mL) on testis development in mice. On postnatal day (PND) 56, we found that TBBPA exerted little effects on testis weight, anogenital distance, sperm parameters, and the serum testosterone level, but resulted in dose-dependent reductions in the seminiferous tubule area coupled with decreased Sertoli cells and spermatogonia and the number of stage VII-VIII seminiferous tubules, and cytoskeleton damage in Sertoli cells, along with down-regulated expression of marker genes for Sertoli cells, spermatogonia and spermatocyte. Further study revealed that the reduced tubule area coupled decreased Sertoli cell and germ cell numbers and marker gene expression also occurred in TBBPA-treated testes on PND 7, along with reduced cell proliferation and disordered arrangement of Sertoli cell nuclei. On PND 15, most of these testicular alterations were still observed in TBBPA-treated males, and cytoskeleton damage in Sertoli cells became observable. All observations convincingly demonstrate that postnatal exposure to TBBPA disturbed testis development in early life and ultimately caused adverse outcomes in adult testes, and that cell proliferation inhibition, the reduction in the seminiferous tubule area coupled decreased Sertoli cell and germ cell numbers and marker gene expression, and cytoskeleton damage in Sertoli cells, are early events contributing to adverse outcomes in adult testes. Our study improves the understanding of reproductive developmental toxicity of TBBPA, highlighting its risk for human health. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47521]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qin, Zhanfen |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Ningxia Med Univ, Key Lab Fertil Preservat & Maintenance, Minist Educ, Yinchuan 750004, Ningxia, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuanyuan,Dong, Mengqi,Xiong, Yiming,et al. Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events[J]. ARCHIVES OF TOXICOLOGY,2022,96(6):1881-1892. |
| APA | Li, Yuanyuan.,Dong, Mengqi.,Xiong, Yiming.,Chang, Qing.,Chen, Xuanyue.,...&Qin, Zhanfen.(2022).Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events.ARCHIVES OF TOXICOLOGY,96(6),1881-1892. |
| MLA | Li, Yuanyuan,et al."Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events".ARCHIVES OF TOXICOLOGY 96.6(2022):1881-1892. |
入库方式： OAI收割
来源：生态环境研究中心
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