Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway
文献类型：期刊论文
| 作者 | Xu, Li ; Liu, Yiyun; Chen, Yangsheng; Zhu, Ruihong; Li, Siqi; Zhang, Songyan; Zhang, Jian; Xie, Heidi Qunhui; Zhao, Bin
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 234期号:0页码:113357 |
| 关键词 | TUMOR-SUPPRESSOR ACTIVITY GENE-EXPRESSION DOWN-REGULATION CANCER CELLS IN-VITRO INVASION AGONIST TARGET GROWTH 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN |
| ISSN号 | 0147-6513 |
| 英文摘要 | Aryl hydrocarbon receptor (AhR) is a ligand-activated receptor to mediates the biological reactions of many environmental and natural compounds, which is highly expressed in glioblastoma. Although it has been reported that AhR agonist emodin can suppress some kinds of tumors, its inhibitory effect on glioblastoma migration and its relationship with AhR remain unclear. Based on the complexity of tumor pathogenesis and the tissue specificity of AhR, we hope can further understand the effect of emodin on glioblastoma and explore its mechanism. We found that the inhibitory effect of emodin on the migration of U87 glioblastoma cells increased with time, and the cell migration ability was inhibited by about 25% after 36 h exposure. In this process, emodin promoted the expression of the tumor suppressor IL24 by activating the AhR signaling pathway. Reducing the expression of AhR or IL24 by interfering RNA could block or relieve the inhibitory effect of emodin on the U87 cells migration, which indicates the inhibition of emodin on the migration of glioblastoma is mediated by the AhR-IL24 axis. Our data proved the AhR-IL24 signal axis is an important pathway for emodin to inhibit the migration of glioblastoma, and the AhR signaling pathway can be used as a key target to research the regulation effect and its mechanism of compounds on glioblastoma migration. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47527]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Xie, Heidi Qunhui |
| 作者单位 | 1.Univ Chinese Acad Sci, Inst Environm & Hlth, Hangzhou Inst Adv Study, Hangzhou, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China 5.Shenzhen Univ, Hlth Sci Ctr, Engn Lab Shenzhen Nat Small Mol Innovat Drugs, Shenzhen, Peoples R |
| 推荐引用方式 GB/T 7714 | Xu, Li,Liu, Yiyun,Chen, Yangsheng,et al. Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,234(0):113357. |
| APA | Xu, Li.,Liu, Yiyun.,Chen, Yangsheng.,Zhu, Ruihong.,Li, Siqi.,...&Zhao, Bin.(2022).Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,234(0),113357. |
| MLA | Xu, Li,et al."Emodin inhibits U87 glioblastoma cells migration by activating aryl hydrocarbon receptor (AhR) signaling pathway".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 234.0(2022):113357. |
入库方式： OAI收割
来源：生态环境研究中心
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