Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection
文献类型：期刊论文
| 作者 | Jin, Xiaoting; Zhang, Jingxu; Li, Yanting; Zhang, Ze; Cui, Tenglong; Wang, Yuanyuan ; Yao, Linlin; Yang, Xiaoxi; Qu, Guangbo; Zheng, Yuxin
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 56期号:3页码:1854-1863 |
| ISSN号 | 0013-936X |
| 关键词 | AIR-POLLUTION EXPRESSION ACE2 ASSOCIATION SPIKE |
| 英文摘要 | Virus receptors are highly involved in mediating the entrance of infectious viruses into host cells. Here, we found that typical chemical exposure caused the upregulation of virus receptor mRNA levels. Chemicals with the same structural characteristics can affect the transcription of angiotensin-converting enzyme 2 (ACE2), a dominant receptor of SARS-CoV-2. Some chemicals can also regulate the transcription of ACE2 by similar regulatory mechanisms, such as multilayer biological responses and the crucial role of TATA-box binding protein associated factor 6. The abovementioned finding suggested that chemical mixtures may have a joint effect on the ACE2 mRNA level in the real scenario, where humans are exposed to numerous chemicals simultaneously in daily life. Chemically regulated virus receptor transcription was in a tissue-dependent manner, with the highest sensitivity in pulmonary epithelial cells. Therefore, in addition to genetic factors, exogenous chemical exposure can be an emerging nongenetic factor that stimulates the transcription of virus receptor abundance and may elevate the protein expression. These alterations could ultimately give rise to the susceptibility to virus infection and disease severity. This finding highlights new requirements for sufficient epidemiological data about exposomes on pathogen receptors in the host. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47533]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qu, Guangbo |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.UCAS, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310000, Peoples R China 4.Qingdao Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Xiaoting,Zhang, Jingxu,Li, Yanting,et al. Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(3):1854-1863. |
| APA | Jin, Xiaoting.,Zhang, Jingxu.,Li, Yanting.,Zhang, Ze.,Cui, Tenglong.,...&Jiang, Guibin.(2022).Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(3),1854-1863. |
| MLA | Jin, Xiaoting,et al."Exogenous Chemical Exposure Increased Transcription Levels of the Host Virus Receptor Involving Coronavirus Infection".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.3(2022):1854-1863. |
入库方式： OAI收割
来源：生态环境研究中心
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