Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of beta cells
文献类型：期刊论文
| 作者 | Qin, Weiping; Ren, Xiaomin; Zhao, Lixia ; Guo, Lianghong
|
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2022-05 |
| 卷号 | 115期号:0页码:162-172 |
| ISSN号 | 1001-0742 |
| 关键词 | PERFLUOROALKYL SUBSTANCES PFASS OXIDATIVE STRESS GLUCOSE-HOMEOSTASIS DIABETES-MELLITUS ACID EXPOSURE EXPRESSION APOPTOSIS GENE DYSFUNCTION ASSOCIATION |
| 英文摘要 | Per- and polyfluoroalkyl substances (PFAS) are found to have multiple adverse outcomes on human health. Recently, epidemiological and toxicological studies showed that exposure to PFAS had adverse impacts on pancreas and showed association with insulin abnormalities. To explore how PFAS may contribute to diabetes, we studied impacts of perfluorooctane sulfonate (PFOS) on cell viability and insulin release capacity of pancreatic fi cells by using in vivo and in vitro methods. We found that 28-day administration with PFOS (10 mg/(kg body weight center dot day)) caused reductions of pancreas weight and islet size in male mice. PFOS administration also led to lower serum insulin level both in fasting state and after glucose infusion among male mice. For cell-based in vitro bioassay, we used mouse fi-TC-6 cancer cells and found 48-hr exposure to PFOS decreased the cell viability at 50 mu mol/L. By measuring insulin content in supernatant, 48-hr pretreatment of PFOS (100 mu mol/L) decreased the insulin release capacity of fi-TC-6 cells after glucose stimulation. Although these concentrations were higher than the environmental concentration of PFOS, it might be reasonable for high concentration of PFOS to exert observable toxic effects in mice considering mice had a faster removal efficiency of PFOS than human. PFOS exposure (50 mu mol/L) to fi-TC-6 cells induced intracellular accumulation of reactive oxidative specie (ROS). Excessive ROS induced the reactive toxicity of cells, which eventually invoke apoptosis and necrosis. Results in this study provide evidence for the possible causal link of exposure to PFOS and diabetes risk. (c) 2021 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47536]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Guo, Lianghong |
| 作者单位 | 1.China Jiliang Univ, Inst Environm & Hlth Sci, Hangzhou 310018, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Weiping,Ren, Xiaomin,Zhao, Lixia,et al. Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of beta cells[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2022,115(0):162-172. |
| APA | Qin, Weiping,Ren, Xiaomin,Zhao, Lixia,&Guo, Lianghong.(2022).Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of beta cells.JOURNAL OF ENVIRONMENTAL SCIENCES,115(0),162-172. |
| MLA | Qin, Weiping,et al."Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of beta cells".JOURNAL OF ENVIRONMENTAL SCIENCES 115.0(2022):162-172. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。