HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant
文献类型：期刊论文
| 作者 | Xu, Tong ; Hu, Xiaoxu; Yang, Guanglei; Liu, Yiyun; Zhang, Qian; Yu, Shuyuan; Chen, Guomin; Li, Yunping; Sha, Rui; Chen, Yangsheng
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
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| 出版日期 | 2022-06-15 |
| 卷号 | 432期号:0页码:128718 |
| ISSN号 | 0304-3894 |
| 关键词 | ARYL-HYDROCARBON RECEPTOR HALOGENATED CARBAZOLES TUMOR ANGIOGENESIS HYPOXIA DIOXIN VEGF HIF-1-ALPHA SYSTEM CANCER OXYGEN |
| 英文摘要 | The dioxin-like substances polyhalogenated carbazoles (PHCZs) may trigger the aryl hydrocarbon receptor (AhR) signaling pathway. Although the crosstalk between AhR and the hypoxia inducible factor-1 (HIF-1) pathways is generally believed to occur, the exact mechanisms of the HIF-1 pathway in PHCZ toxicity have not been determined. We aimed to elucidate the effect of PHCZs on the HIF-1 pathway and its involvement in the regulation of target genes of HIF-1. Herein, we employed human HepG2 cells transiently transfected with a hypoxia response element (HRE) luciferase reporter to identify PHCZs that could influence HIF-1 pathway. We found that exposure to one of the four selected PHCZs, specifically 1,3,6,8-tetrabromo-9 H-carbazole (1368-BCZ), induced a significant enhancement of the activity of HRE activity. In silico data supported 1368-BCZ-induced HIF-1 alpha activity preferentially. Moreover, 1368-BCZ significantly upregulated the expression of HIF-1 target genes, including endothelial growth factor (VEGF) and erythropoietin. Importantly, the stimulated secretion of VEGF by 1368-BCZ promoted the angiogenesis in human umbilical vein endothelial cells. Therefore, the present |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47544]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Xu, Li |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Beijing Hosp, Natl Ctr Gerontol, Dept Cardiol, Beijing 100730, Peoples R China 5.Shenzhen Ctr Dis Control & Prevent, Environm & Hlth Dept, Shenzhen 518055, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Tong,Hu, Xiaoxu,Yang, Guanglei,et al. HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,432(0):128718. |
| APA | Xu, Tong.,Hu, Xiaoxu.,Yang, Guanglei.,Liu, Yiyun.,Zhang, Qian.,...&Zhao, Bin.(2022).HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant.JOURNAL OF HAZARDOUS MATERIALS,432(0),128718. |
| MLA | Xu, Tong,et al."HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant".JOURNAL OF HAZARDOUS MATERIALS 432.0(2022):128718. |
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来源：生态环境研究中心
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