Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma
文献类型：期刊论文
| 作者 | Li, Zhe; Zhang, Hao; Cai, Chunjing; Lin, Zhong; Zhen, Zhen; Chu, Jie; Guo, Kai |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2022-04 |
| 卷号 | 106期号:8页码:3033-3049 |
| 关键词 | NUCLEOTIDE EXCISION-REPAIR PROGRAMMED CELL-DEATH MEMBRANE H+-ATPASE OXIDATIVE STRESS GROWTH GCN5 TRANSPORT SALINITY REESEI METABOLISM |
| ISSN号 | 0175-7598 |
| 英文摘要 | Trichoderma viride has a wide range of applications in plant growth promotion, biological control, cellulase production, and biomass utilization. Salinity is a major limitation to Trichoderma strains in the natural environment and fermentation environment, and to improve the adaptability of Trichoderma to salt stress is of great significance to its applications in industry and agriculture. Histone acetylation plays important roles in the regulation of physiological and biochemical processes including various stress responses. GCN5 is the most representative histone acetylase, which plays vital roles in chromatin remodeling of promoters to facilitate the transcription activation. In this paper, we identified a GCN5-encoding gene TvGCN5 in T. viride Tv-1511, and characterized the function and regulating mechanism of TvGCN5-mediated acetylation of histone H3 in the salt adoption of Tv-1511, by constructions of the deletion mutants (Tv-1511-Delta GCN5) and overexpression mutants (Tv-1511-GCN5-OE) of TvGCN5. Results showed that compared with wild-type Tv-1511, the over-expression of TvGCN5 resulted in the longer mycelia diameter and more biomass under salt stress. Furthermore, Tv-1511-Delta GCN5 strains obtained the improved sodium (Na+) compartmentation and antioxidant capacity by upregulating the transcriptional levels of genes encoding PM H+ -ATPase, vacuolar H+ -ATPase, and antioxidant enzymes. Notably, the changes in the transcriptional expressions of these genes are tightly modulated by the TvGCN5-mediated acetylated level of histone H3 in their promoter regions. In all, these results reveal that TvGCN5 plays an important role in stress tolerance of T. viride Tv-1511, and provides potential insight to facilitate the application of epigenetic modulation in the expanding utilization of Trichoderma. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47547]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Li, Zhe |
| 作者单位 | 1.Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan 250014, Peoples R China 2.Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China 3.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 10085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhe,Zhang, Hao,Cai, Chunjing,et al. Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2022,106(8):3033-3049. |
| APA | Li, Zhe.,Zhang, Hao.,Cai, Chunjing.,Lin, Zhong.,Zhen, Zhen.,...&Guo, Kai.(2022).Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,106(8),3033-3049. |
| MLA | Li, Zhe,et al."Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 106.8(2022):3033-3049. |
入库方式： OAI收割
来源：生态环境研究中心
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