Inflammation and accompanied disrupted hematopoiesis in adult mouse induced by rare earth element nanoparticles
文献类型：期刊论文
| 作者 | Gao, Jie ; Wang, Shunhao; Tang, Gang; Wang, Ziniu; Wang, Yuanyuan; Wu, Qi; Yang, Xiaoxi; Liu, Yanna; Hu, Ligang; He, Bin
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2022-07-20 |
| 卷号 | 831期号:0页码:155416 |
| ISSN号 | 0048-9697 |
| 关键词 | IN-VIVO BIODISTRIBUTION ENGINEERED NANOMATERIALS GADOLINIUM CHLORIDE LIVER INFLAMMATION MACROPHAGES TOXICITY SOIL DIAGNOSIS EXPOSURE GRAPHENE |
| 英文摘要 | Rare earth element nanoparticles (REE NPs) or agents have been used extensively in various fields. Human exposure to REE NPs is an increasing concern. To date, REE NP-mediated comprehensive immune responses after incorporation into the body remain unclear. In our study, using gadolinium oxide NPs (Gd2O3) as a typical REE NP, we systematically investigated immune responses in vivo. The liver and spleen were the main sites where Gd2O3 retained and accumulated, while Gd2O3 content per unit tissue mass in the spleen was 4.4 times higher than that in the liver. Gd2O3 increased the number of monocyte-derived macrophages and myeloid-derived dendritic cells (M-DCs) in the liver. In the spleen, Gd2O3 caused infiltration of neutrophils, M-DCs, and B cells. The accumulation of Gd2O3 in the liver or spleen also contributed to an increased concentration of cytokines in peripheral blood. In both the bone marrow and spleen, Gd2O3 led to increased populations of hematopoietic stem cells (HSCs), multipotent progenitors, and common lymphoid progenitors. Compared to the decreased monocytes in peripheral blood on day 2, a significant decrease of circulating lymphocytes on day 7 was still observed, suggesting the exposure duration led to variable effects. This might be explained by the sustained accumulation of Gd2O3 in the liver and spleen. Together, our study systemically depicted the alterations in mature immune alterations together with hematopoiesis in both myeloid and lymphoid lineages induced by Gd2O3 exposure. Our findings will facilitate a comprehensive understanding of the interactions of immune system with REE NPs in vivo. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47555]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qu, Guangbo |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 3.UCAS, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310000, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Jie,Wang, Shunhao,Tang, Gang,et al. Inflammation and accompanied disrupted hematopoiesis in adult mouse induced by rare earth element nanoparticles[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,831(0):155416. |
| APA | Gao, Jie.,Wang, Shunhao.,Tang, Gang.,Wang, Ziniu.,Wang, Yuanyuan.,...&Jiang, Guibin.(2022).Inflammation and accompanied disrupted hematopoiesis in adult mouse induced by rare earth element nanoparticles.SCIENCE OF THE TOTAL ENVIRONMENT,831(0),155416. |
| MLA | Gao, Jie,et al."Inflammation and accompanied disrupted hematopoiesis in adult mouse induced by rare earth element nanoparticles".SCIENCE OF THE TOTAL ENVIRONMENT 831.0(2022):155416. |
入库方式： OAI收割
来源：生态环境研究中心
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