Insights into the toxicokinetic, tissue distribution and maternal transfer of polychlorinated dibenzo-p-dioxins/dibenzofurans in laying hens fed with dioxin-associated dietary
文献类型：期刊论文
| 作者 | Wang, Chu; Dong, Shujun; Wang, Pu; Hao, Yanfen; Wang, Ruiguo; Zhang, Qinghua; Jiang, Guibin
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2022-04-10 |
| 卷号 | 816期号:0页码:151664 |
| ISSN号 | 0048-9697 |
| 关键词 | CONGENER-SPECIFIC METABOLISM BIPHENYLS PCBS HEPATIC SEQUESTRATION COMMON CORMORANTS FLAME RETARDANTS LAKE BIWA PCDD/FS EGGS BIOACCUMULATION RESIDUES |
| 英文摘要 | A controlled feeding experiment was conducted to investigate the toxicokinetic of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) in laying hens. The laying hens were fed with fly ash contaminated diets to rep-licate the typical environment-feed-chicken transfer chain in China. Levels of PCDD/Fs rapidly increased in the pectoralis, adipose tissue, liver and blood of laying hens with daily ingestion of dioxin-associated diets during the 14-days exposure period, and then a gradual decrease was observed in the 28-days depletion period. The de-pletion rates (k(d)) of the toxic equivalent of PCDD/Fs (TEQ(PCDD/Fs)) were 0.043, 0.031 and 0.030 day(-1) for pectoralis, liver and adipose tissue in the high-exposure group, respectively. The k(d) of individual PCDD/Fs in liver increased with the numbers of chlorine and n-octanol/water partition coefficient (logK(OW)), indicating that lower chlorinated congeners had higher half-lives in liver. Decreasing ratios of liver to adipose tissue for PCDD/Fs (L/AT) throughout the experiment suggested a tendency of equilibrium partitioning between liver and adipose tissue. Congener-specific sequestration of PCDD/Fs in liver was revealed by the positive correlation between L/AT ratios and logK(OW). Physiological bioconcentration factors of PCDD/Fs were estimated at the end of exposure, indicating the preferential accumulation of hexachlorinated congeners in most tissues. Furthermore, maternal transfer of PCDD/Fs was positively correlated with logK(OW), implying that more lipophilic congeners were transferred to egg along with the lipid circulation. (C) 2021 Elsevier B.V. All rights reserved. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47556]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Wang, Pu |
| 作者单位 | 1.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China 4.Jianghan Univ, Sch Environm & Hlth, Hubei Key Lab Ind Fume & Dust Pollut Control, Wuhan 430056, Peoples R China 5.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chu,Dong, Shujun,Wang, Pu,et al. Insights into the toxicokinetic, tissue distribution and maternal transfer of polychlorinated dibenzo-p-dioxins/dibenzofurans in laying hens fed with dioxin-associated dietary[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,816(0):151664. |
| APA | Wang, Chu.,Dong, Shujun.,Wang, Pu.,Hao, Yanfen.,Wang, Ruiguo.,...&Jiang, Guibin.(2022).Insights into the toxicokinetic, tissue distribution and maternal transfer of polychlorinated dibenzo-p-dioxins/dibenzofurans in laying hens fed with dioxin-associated dietary.SCIENCE OF THE TOTAL ENVIRONMENT,816(0),151664. |
| MLA | Wang, Chu,et al."Insights into the toxicokinetic, tissue distribution and maternal transfer of polychlorinated dibenzo-p-dioxins/dibenzofurans in laying hens fed with dioxin-associated dietary".SCIENCE OF THE TOTAL ENVIRONMENT 816.0(2022):151664. |
入库方式： OAI收割
来源：生态环境研究中心
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