Intrusion of inhaled exotic ultrafine particles into the knee joint in humans and animals: A risk to the joint and surrounding tissues
文献类型：期刊论文
| 作者 | Qi, Yu ; Wei, Shuting; Chen, Yucai; Pu, Yichen; Liu, Sijin; Liu, Yajun
|
| 刊名 | NANO TODAY
 |
| 出版日期 | 2022-04 |
| 卷号 | 43期号:0页码:101426 |
| ISSN号 | 1748-0132 |
| 关键词 | AIR-POLLUTION INHALATION EXPOSURE NANOPARTICLES TOXICITY ALTERS |
| 英文摘要 | Mounting evidence recognizes a close connection between air pollution and arthropathy. Although the indirect effects of ultrafine particles (UFPs) on the joints, i.e., by inducing the inflammatory cytokines, has been documented, there are still significant knowledge gaps in understanding the direct threat of exotic particles to the joint. In the current study, we uncovered exotic UFPs in human knee joint effusions of osteoarthritis patients, and identified the ambient environmental exposure sources of these UFPs, including natural mineral and metal oxide particles (i.e., donpeacorite and hematite) through figuring out their chemical and structural fingerprints. Furthermore, animal experiments unveiled the translocation of in-haled UFPs into the joint. Histological examination recognized significant injuries to the synovium and cartilage in response to the intrusion of UFPs in the joint. With the aid of isotope-labelling, we substantiated the invasion of UFPs in the joints and obtained the according retention kinetics in mice. Collectively, our combined results provide direct evidence of the intrusion of exotic particles into the joint cavities, and define the translocation for inhaled UFPs from the inhalation system into the joints and impairment of the joint protection system. This work provides additional insights for the continued investigations into the adverse effects of air pollution on the joints, and has crucial implications in public health measures par-ticularly related to air pollution.(c) 2022 The Author(s). Published by Elsevier Ltd. CC_BY_NC_ND_4.0 |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47558]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Liu, Sijin |
| 作者单位 | 1.Shandong First Med Univ & Shandong Acad Med Sci, Med Sci & Technol Innovat Ctr, Jinan 250117, S 2.Peking Univ, Beijing Jishuitan Hosp, Hlth Sci Ctr, Beijing 100035, Peoples R China 3.Jiangsu Huajing Mol Imaging & Drug Res Inst Co Lt, Changshu 215500, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Yu,Wei, Shuting,Chen, Yucai,et al. Intrusion of inhaled exotic ultrafine particles into the knee joint in humans and animals: A risk to the joint and surrounding tissues[J]. NANO TODAY,2022,43(0):101426. |
| APA | Qi, Yu,Wei, Shuting,Chen, Yucai,Pu, Yichen,Liu, Sijin,&Liu, Yajun.(2022).Intrusion of inhaled exotic ultrafine particles into the knee joint in humans and animals: A risk to the joint and surrounding tissues.NANO TODAY,43(0),101426. |
| MLA | Qi, Yu,et al."Intrusion of inhaled exotic ultrafine particles into the knee joint in humans and animals: A risk to the joint and surrounding tissues".NANO TODAY 43.0(2022):101426. |
入库方式： OAI收割
来源：生态环境研究中心
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