Iron oxide nanoparticles oxidize transformed RAW 264.7 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine
文献类型：期刊论文
| 作者 | Li, Haidong; Tao, Xiaoqi; Song, Erqun; Song, Yang
|
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2022-08 |
| 卷号 | 300期号:0页码:134617 |
| 关键词 | OXIDATIVE STRESS LIPID-ACCUMULATION HYDROXYL RADICALS INHALATION LIPOPROTEIN STABILITY EXTRACTS PROTECT SILICA MODEL |
| ISSN号 | 0045-6535 |
| 英文摘要 | Iron oxide nanoparticles (IONPs) are one of the most important components in airborne particulate matter that originally generated from traffic emission, iron ore mining, coal combustion and melting of engine fragments. Once IONPs entered respiratory tract and deposit in the alveoli, they may interact with pulmonary surfactant (PS) that distributed in the alveolar lining. Thereafter, it is necessary to investigate the interaction of inhaled IONPs and PS, which helps the understanding of health risk of respiratory health induced by IONPs. Using dipalmitoyl phosphatidylcholine (DPPC), the major components of PS, as a lipid model, we explored the interaction of DPPC with typical IONPs, Fe3O4 NPs and amino-functionalized analogue (Fe3O4-NH2 NPs). DPPC was readily adsorbed on the surface of both IONPs. Although DPPC corona depressed the cellular uptake of IONPs, IONPs@DPPC complexes caused higher cytotoxicity toward RAW 264.7 macrophages, compared to pristine IONPs. Mechanistic studies have shown that IONPs react with intracellular hydrogen peroxide, which promotes the Fenton reaction, to generate hydroxyl radicals. Iron ions could oxidize lipids to form lipid peroxides, and lipid hydroperoxides will decompose to generate hydroxyl radicals, which further promote cellular oxidative stress, lipid accumulation, foam cell formation, and the release of inflammatory factors. These findings demonstrated the phenomenon of coronal component oxidation, which contributed to IONPs-induced cytotoxicity. This study offered a brand-new toxicological mechanism of IONPs at the molecular level, which is helpful for further understanding the adverse effects of IONPs. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47559]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Tao, Xiaoqi |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China 2.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, 2 Tiansheng Rd, Chongqing 400715, Peoples R China 3.Southwest Univ, Coll Food Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, 2 Tiansheng Rd, Chongqing 400715, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Haidong,Tao, Xiaoqi,Song, Erqun,et al. Iron oxide nanoparticles oxidize transformed RAW 264.7 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine[J]. CHEMOSPHERE,2022,300(0):134617. |
| APA | Li, Haidong,Tao, Xiaoqi,Song, Erqun,&Song, Yang.(2022).Iron oxide nanoparticles oxidize transformed RAW 264.7 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine.CHEMOSPHERE,300(0),134617. |
| MLA | Li, Haidong,et al."Iron oxide nanoparticles oxidize transformed RAW 264.7 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine".CHEMOSPHERE 300.0(2022):134617. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。