Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor
文献类型：期刊论文
| 作者 | Wei, Yongyi; Sun, Hainan; Zhang, Songyan; Xie, Heidi Qunhui; Li, Cong; Zhao, Bin ; Yan, Bing
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2022-05-15 |
| 卷号 | 430期号:0页码:128458 |
| ISSN号 | 0304-3894 |
| 关键词 | QUANTUM DOTS 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN NANOPARTICLES ACTIVATION PERTURBATION EXPRESSION CANCER TCDD AHR ROS |
| 英文摘要 | Despite numerous studies on effects of environmental accumulation of nano-pollutants, the influence of nanoparticles on the biological perturbations of coexisting pollutants in the environment remained unknown. The present study aimed at elucidating the perturbations of six environmental nanoparticles on detoxification of dioxin-induced toxicity at cellular level. We discovered that there was no remarkable difference in the cell uptake and intracellular distributions of these six nanoparticles. However, they have different effects on the detoxification of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Multi-walled carbon nanotubes (MWCNTs) inhibited the translocation of aryl hydrocarbon receptor (AhR) from cytosol to the nucleus, leading to the downregulation of cytochrome P450 family 1 subfamily A member 1 (CYP1A1) and inhibition of detoxification function. These findings demonstrate that MWCNTs can impact the potential detoxification of dioxin-induced toxicity through of (2022) modulating AhR signaling pathway. Co-exposures to MWCNTs and dioxin may cause even more toxicity than single exposure to dioxin or MWCNTs alone. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47581]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China 2.Guangzhou Univ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China 3.Shandong Vocat Coll Light Ind, Zibo 255300, Peoples R China 4.Shenzhen Univ, Hlth Sci Ctr, Engn Lab Shenzhen Nat Small Mol Innovat Drugs, Shenzhen 518000, Peoples R China 5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 10 |
| 推荐引用方式 GB/T 7714 | Wei, Yongyi,Sun, Hainan,Zhang, Songyan,et al. Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,430(0):128458. |
| APA | Wei, Yongyi.,Sun, Hainan.,Zhang, Songyan.,Xie, Heidi Qunhui.,Li, Cong.,...&Yan, Bing.(2022).Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor.JOURNAL OF HAZARDOUS MATERIALS,430(0),128458. |
| MLA | Wei, Yongyi,et al."Multi-walled carbon nanotubes inhibit potential detoxification of dioxin-mediated toxicity by blocking the nuclear translocation of aryl hydrocarbon receptor".JOURNAL OF HAZARDOUS MATERIALS 430.0(2022):128458. |
入库方式： OAI收割
来源：生态环境研究中心
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