Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells
文献类型：期刊论文
| 作者 | Chen, Shaokun ; Lai, Weiyi; Li, Xiangjun; Wang, Hailin
|
| 刊名 | CHEMICAL RESEARCH IN TOXICOLOGY
 |
| 出版日期 | 2022-03-21 |
| 卷号 | 35期号:3页码:387-391 |
| 关键词 | MIXED LINEAGE KINASE INHIBITION APOPTOSIS PROTEIN REPAIR NECROPTOSIS CANCER DAMAGE DEATH |
| ISSN号 | 0893-228X |
| 英文摘要 | Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy that causes endless pain for patients and accounts for thousands of deaths worldwide. The development of an effective AML treatment is a topic of ongoing interest. Here, we demonstrated that a pyroptosis inhibitor necrosulfonamide (NSA) can selectively induce highly toxic double-strand breaks and kill AML cells. Mechanistically, reactive oxygen species (ROS) were the key effectors mediating the toxicity of NSA. These results probably indicate that NSA is a novel candidate for the treatment of AML. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47583]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 10085, Peoples R China 3.UCAS, Inst Adv Study, Inst Environm & Hlth, Hangzhou 310000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shaokun,Lai, Weiyi,Li, Xiangjun,et al. Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2022,35(3):387-391. |
| APA | Chen, Shaokun,Lai, Weiyi,Li, Xiangjun,&Wang, Hailin.(2022).Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells.CHEMICAL RESEARCH IN TOXICOLOGY,35(3),387-391. |
| MLA | Chen, Shaokun,et al."Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells".CHEMICAL RESEARCH IN TOXICOLOGY 35.3(2022):387-391. |
入库方式： OAI收割
来源：生态环境研究中心
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