Occurrence of silver-containing particles in rat brains upon intranasal exposure of silver nanoparticles
文献类型：期刊论文
| 作者 | Liu, Nian ; Qu, Guangbo; Wen, Ruoxi; Liu, Xiaolei; Wang, Yuanyuan; Gao, Jie; Yin, Yongguang; Shi, Jianbo; Zhou, Qunfang; He, Bin
|
| 刊名 | METALLOMICS
 |
| 出版日期 | 2022-01-28 |
| 卷号 | 14期号:1页码:mfab077 |
| ISSN号 | 1756-5901 |
| 关键词 | PLASMA-MASS SPECTROMETRY SELENIUM CYTOTOXICITY LOCALIZATION ALZHEIMERS MECHANISM CADMIUM SAMPLES METALS IONS |
| 英文摘要 | The widespread application of silver (Ag) nanomaterials raises health concerns due to the adverse effects that can be associated with silver nanoparticles (AgNPs) exposure. AgNPs can be introduced into human bodies via inhalation, either intentionally (intranasal administration of AgNPs) or unintentionally (environmental pollution, accidental release, or occupational exposure). Recent studies have shown that intranasal exposure of experimental animals to AgNPs can lead to the accumulation of Ag in brain tissues. However, there is little information available concerning what forms of Ag (particulate and ionic) exist in brain tissues. This study aimed to investigate whether particulate Ag exists in rat brains following intranasal exposure of AgNPs at 1 mg/kg/day using multiple analytical techniques. The results demonstrated that Ag-containing particles were presented in AgNPs-exposed rat brains, accounting for 20.2-68.1% of the total Ag. The mass concentrations of Ag-containing particles in brain tissues increased with exposure time but only decreased by 37.5% after elimination for 4 weeks upon exposure cessation. The size of Ag-containing particles identified in rat brains was larger than the original AgNPs. The Ag-containing particles identified in the rat brain were composed of multiple elements, including Ag, sulfur, and selenium with atomic percentages of 45.8%, 37.5%, and 16.7%, respectively. The finding highlighted the occurrence and accumulation of transformed AgNPs containing S and Se in rat brains after intranasal exposure to AgNPs, implying potential risks for brain health. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47589]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Nian,Qu, Guangbo,Wen, Ruoxi,et al. Occurrence of silver-containing particles in rat brains upon intranasal exposure of silver nanoparticles[J]. METALLOMICS,2022,14(1):mfab077. |
| APA | Liu, Nian.,Qu, Guangbo.,Wen, Ruoxi.,Liu, Xiaolei.,Wang, Yuanyuan.,...&Jiang, Guibin.(2022).Occurrence of silver-containing particles in rat brains upon intranasal exposure of silver nanoparticles.METALLOMICS,14(1),mfab077. |
| MLA | Liu, Nian,et al."Occurrence of silver-containing particles in rat brains upon intranasal exposure of silver nanoparticles".METALLOMICS 14.1(2022):mfab077. |
入库方式： OAI收割
来源：生态环境研究中心
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