Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression
文献类型：期刊论文
| 作者 | Zhu, Jianqiang; Fu, Qingfeng; Wang, Shunhao; Ren, Liting; Feng, Wenya; Wei, Shuting; Zhang, Zhihong; Xu, Yong; Ganz, Tomas; Liu, Sijin
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2022-01-26 |
| 卷号 | 22期号:2页码:751-760 |
| ISSN号 | 1530-6984 |
| 关键词 | PD NANOSHEETS MOUSE MODEL INFLAMMATION TOCILIZUMAB IRON NANOPARTICLES PATHOGENESIS PREVALENCE PROMOTES |
| 英文摘要 | In recent years, targeted therapies and immunotherapeutics, along with conventional chemo- and radiotherapy, have greatly improved cancer treatments. Unfortunately, in cancer patients, anemia, either as a complication of cancer progression or as the result of cancer treatment, undermines the expected therapeutic efficacy. Here, we developed a smart nanosystem based on the palladium nanoplates (PdPLs) to deliver tocilizumab (TCZ, a widely used IL-6R antibody) to the liver for specific blockade of IL-6/IL-6R signaling to correct anemia. With chemical modifications, this nanosystem delivered a large mass of TCZ and enhanced liver delivery, inducing a marked suppression of hepcidin expression as a result of diminished IL-6 signaling. Through this mechanism, significant suppression of tumor progression was realized (at least in part) because of the corrected anemia after treatment. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47596]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Tianjin Med Univ, Tianjin Inst Urol, Dept Urol, Hosp 2, Tianjin 300211, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Jianqiang,Fu, Qingfeng,Wang, Shunhao,et al. Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression[J]. NANO LETTERS,2022,22(2):751-760. |
| APA | Zhu, Jianqiang.,Fu, Qingfeng.,Wang, Shunhao.,Ren, Liting.,Feng, Wenya.,...&Liu, Sijin.(2022).Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression.NANO LETTERS,22(2),751-760. |
| MLA | Zhu, Jianqiang,et al."Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression".NANO LETTERS 22.2(2022):751-760. |
入库方式： OAI收割
来源：生态环境研究中心
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