Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling
文献类型：期刊论文
| 作者 | Ren, Zhihua; Ku, Tingting; Gao, Yurou; Yang, Xiaoxi ; Meng, Lingyi; Liu, Qian S.; Liang, Jiefeng; Xu, Hanqing; Liao, Chunyang; Zhou, Qunfang
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2022-06-21 |
| 卷号 | 56期号:12页码:8496-8506 |
| ISSN号 | 0013-936X |
| 关键词 | ENDOCRINE-DISRUPTING CHEMICALS EMBRYONIC STEM-CELLS ESTROGEN-RECEPTOR-ALPHA IN-VITRO BISPHENOL-A GENERATION EXPOSURE BINDING |
| 英文摘要 | The neurodevelopmental process is highly vulnerable to environmental stress from exposure to endocrine-disrupting chemicals. Perfluorinated iodine alkanes (PFIs) possess estrogenic activities, while their potential neurodevelopmental toxicity remains blurry. In the present study, the effects of two PFIs, including dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were investigated in the neural differentiation of the mouse embryonic stem cells (mESCs). Without influencing the cytobiological process of the mESCs, PFIs interfered the triploblastic development by increasing ectodermal differentiation, thus promoting subsequent neurogenesis. The temporal regulation of PFIs in Notch-Hes signaling through the targeting of mmumiRNA-34a-5p provided a substantial explanation for the underlying mechanism of PFI-promoted mESC commitment to the neural lineage. The findings herein provided new knowledge on the potential neurodevelopmental toxicities of PFIs, which would help advance the health risk assessment of these kinds of emerging chemicals. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47600]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Zhou, Qunfang |
| 作者单位 | 1.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 2.Univ Chinese Acad Sci, Coll Sino Danish, Beijing 100049, Peoples R China 3.Shanxi Univ, Coll Environm & Resource, Res Ctr Environm & Hlth, Taiyuan 030006, Peoples R China 4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Zhihua,Ku, Tingting,Gao, Yurou,et al. Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022,56(12):8496-8506. |
| APA | Ren, Zhihua.,Ku, Tingting.,Gao, Yurou.,Yang, Xiaoxi.,Meng, Lingyi.,...&Jiang, Guibin.(2022).Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling.ENVIRONMENTAL SCIENCE & TECHNOLOGY,56(12),8496-8506. |
| MLA | Ren, Zhihua,et al."Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling".ENVIRONMENTAL SCIENCE & TECHNOLOGY 56.12(2022):8496-8506. |
入库方式： OAI收割
来源：生态环境研究中心
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