Polychlorinated biphenyl quinone induces immunotoxicity via lymphocytes apoptosis and Th1-Th2 cell imbalance in C57BL/6 mice
文献类型：期刊论文
| 作者 | Peng, Lu; Liu, Jing ; Song, Erqun; Song, Yang
|
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2022-06-10 |
| 卷号 | 824期号:0页码:153870 |
| 关键词 | EXPOSURE CONTRIBUTES METABOLITES RESPONSES SPLEEN TH1 |
| ISSN号 | 0048-9697 |
| 英文摘要 | Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants distributed worldwide. Existing researches indicated that the immune system is one of the most sensitive indicators of adverse health effects caused by PCBs. We for the first time evaluated the immunotoxic effect of PCB29-pQ, an active quinone-type PCB metabolite. After PCB29pQ exposure, the body weight of the mice was reduced, but increased the organ index of the spleen and lungs. The morphology and structure of the mouse spleen and lungs were changed, and partial types of lymphocyte subsets in the spleen were significantly reduced. The activation of caspase-3, the significant up-regulation of Bax and the decrease of Bcl-2 indicated occurrence of apoptosis. In addition, mRNA results showed that PCB29-pQ caused the imbalance of Th1/Th2 cytokines and promoted the Th1-type immune response. Taken together, the above results demonstrated that treatment with PCB29-pQ induced spleen immune dysfunction targeting the apoptosis pathway and Th1/Th2 cytokines imbalance in mice. Since the immune system plays a fundamental role in maintaining homeostasis and is strongly involved in the development of diseases, this study provides a new insight into the immunotoxicity mechanism of PCBs. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47603]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Song, Yang |
| 作者单位 | 1.Southwest Univ, Coll Pharmaceut Sci, Minist Educ, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China 2.Guizhou Minzu Univ, Coll Ecoenvironm Engn, Guiyang 550025, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Lu,Liu, Jing,Song, Erqun,et al. Polychlorinated biphenyl quinone induces immunotoxicity via lymphocytes apoptosis and Th1-Th2 cell imbalance in C57BL/6 mice[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,824(0):153870. |
| APA | Peng, Lu,Liu, Jing,Song, Erqun,&Song, Yang.(2022).Polychlorinated biphenyl quinone induces immunotoxicity via lymphocytes apoptosis and Th1-Th2 cell imbalance in C57BL/6 mice.SCIENCE OF THE TOTAL ENVIRONMENT,824(0),153870. |
| MLA | Peng, Lu,et al."Polychlorinated biphenyl quinone induces immunotoxicity via lymphocytes apoptosis and Th1-Th2 cell imbalance in C57BL/6 mice".SCIENCE OF THE TOTAL ENVIRONMENT 824.0(2022):153870. |
入库方式： OAI收割
来源：生态环境研究中心
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