Polystyrene Nanoplastics Induce Neutrophil Extracellular Traps in Mice Neutrophils
文献类型：期刊论文
| 作者 | Zhu, Xiangyu ; Peng, Lu; Song, Erqun; Song, Yang
|
| 刊名 | CHEMICAL RESEARCH IN TOXICOLOGY
 |
| 出版日期 | 2022-03-21 |
| 卷号 | 35期号:3页码:378-382 |
| 关键词 | NETOSIS INFECTION |
| ISSN号 | 0893-228X |
| 英文摘要 | With growing applications of plastic products, there is a growing threat to human health. Therefore, it is important to understand their toxicological behaviors. The release of neutrophil extracellular traps (NETs) was clarified as a new immune defense mechanism against intruders. Here, we discovered that polystyrene nanoplastics (PS NPs) induce NET formation, with involvement of reactive oxygen species, peptidyl arginine deiminase 4 (PAD4), and neutrophil elastase. Moreover, overexpression of PAD4 induced by PS NPs further mediates histone citrullination and chromatin depolymerization. These results provide important information and promising strategies for safety and immunotoxicity assessment of NPs. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47604]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Song, Yang |
| 作者单位 | 1.Southwest Univ, Coll Pharmaceut Sci, Key Lab Luminescence Anal & Mol Sensing, Minist Educ, Chongqing 400715, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Xiangyu,Peng, Lu,Song, Erqun,et al. Polystyrene Nanoplastics Induce Neutrophil Extracellular Traps in Mice Neutrophils[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2022,35(3):378-382. |
| APA | Zhu, Xiangyu,Peng, Lu,Song, Erqun,&Song, Yang.(2022).Polystyrene Nanoplastics Induce Neutrophil Extracellular Traps in Mice Neutrophils.CHEMICAL RESEARCH IN TOXICOLOGY,35(3),378-382. |
| MLA | Zhu, Xiangyu,et al."Polystyrene Nanoplastics Induce Neutrophil Extracellular Traps in Mice Neutrophils".CHEMICAL RESEARCH IN TOXICOLOGY 35.3(2022):378-382. |
入库方式： OAI收割
来源：生态环境研究中心
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