Subacute effects of the chlorinated flame retardant dechlorane 602 on intestinal microenvironment in mice
文献类型：期刊论文
| 作者 | Li, Yunping; Xie, Heidi Qunhui; Liu, Yin; Xu, Li ; Zheng, Liping; Yu, Shuyuan; Chen, Guomin; Ji, Jiajia; Jiang, Shuai; Guo, Tai L.
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| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2022-08 |
| 卷号 | 166期号:0页码:107394 |
| ISSN号 | 0160-4120 |
| 关键词 | OXIDATIVE STRESS RETINOIC ACID MODULATION MECHANISM TOXICITY EXPOSURE CELLS |
| 英文摘要 | Background: Chlorinated flame retardant Dechlorane 602 (Dec 602) has been detected in daily food, indicating that it may pose a risk to intestinal health. The intestinal microenvironment plays an important role in intestinal health. Intestinal microbiota and metabolites are two important factors for maintaining the microenvironment. However, little is known about the effects of Dec 602 on intestinal microbiota and metabolites.Objectives: We aimed to probe the effects of Dec 602 on the intestine by revealing the changes that Dec 602 caused to the intestinal microbiota and metabolites.Methods: Adult female C57BL/6 mice were exposed to Dec 602 (low/high doses: 1.0/10.0 mu g/kg body weight per day) orally for 7 consecutive days, and sacrificed after 7 days of recovery. The composition of colonic microbiota was measured by 16S rRNA gene sequencing, and the colonic metabolites were determined by LC-ESI-MS/MS. Finally, the effects of Dec 602 on the colon were validated by histopathological analysis.Results: The intestinal microbiota composition was altered toward a pro-inflammatory status after exposure to Dec 602. Dec 602 exposure also up-regulated oxidative metabolites (glutathione disulfide, taurine and retinoic acid) and pro-inflammatory metabolites (prostaglandin E2). On the other hand, antioxidative metabolites (sadenosylmethionine and 11-cis-retinol) and anti-inflammatory metabolites (alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid) were down-regulated after exposure to Dec 602. Infiltration of lymphocytes in the colonic lamina propria was observed in the mice treated with Dec 602 for 7 days, and it was not recovered after another 7 days without further treatment.Conclusion: Dec 602 interfered with the colonic microbiota and metabolome, and exhibited inflammatory features. Histopathological studies confirmed that Dec 602 exposure did induce colonic inflammation. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47622]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Guo, Tai L. |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Georgia, Dept Vet Biomed Sci, Athens, GA 30602 USA 3.Shenzhen Ctr Dis Control & Prevent, Environm & Hlth Dept, Shenzhen 518055, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Environm, Hangzhou 310024, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yunping,Xie, Heidi Qunhui,Liu, Yin,et al. Subacute effects of the chlorinated flame retardant dechlorane 602 on intestinal microenvironment in mice[J]. ENVIRONMENT INTERNATIONAL,2022,166(0):107394. |
| APA | Li, Yunping.,Xie, Heidi Qunhui.,Liu, Yin.,Xu, Li.,Zheng, Liping.,...&Zhao, Bin.(2022).Subacute effects of the chlorinated flame retardant dechlorane 602 on intestinal microenvironment in mice.ENVIRONMENT INTERNATIONAL,166(0),107394. |
| MLA | Li, Yunping,et al."Subacute effects of the chlorinated flame retardant dechlorane 602 on intestinal microenvironment in mice".ENVIRONMENT INTERNATIONAL 166.0(2022):107394. |
入库方式： OAI收割
来源：生态环境研究中心
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