Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis
文献类型：期刊论文
| 作者 | Dong, Mengqi; Li, Yuanyuan ; Zhu, Min; Li, Jinbo; Qin, Zhanfen
|
| 刊名 | MOLECULES
 |
| 出版日期 | 2022-01 |
| 卷号 | 27期号:1页码:249 |
| 关键词 | AMPHIBIAN METAMORPHOSIS GENE-EXPRESSION EXPOSURE TBBPA MODEL TISSUE NOTCH ASSAY MILK FATE |
| 英文摘要 | Although tetrabromobisphenol A (TBBPA) has been well proven to disturb TH signaling in both in vitro and in vivo assays, it is still unclear whether TBBPA can affect brain development due to TH signaling disruption. Here, we employed the T3-induced Xenopus metamorphosis assay (TIXMA) and the spontaneous metamorphosis assay to address this issue. In the TIXMA, 5-500 nmol/L TBBPA affected T3-induced TH-response gene expression and T3-induced brain development (brain morphological changes, cell proliferation, and neurodifferentiation) at premetamorphic stages in a complicated biphasic concentration-response manner. Notably, 500 nmol/L TBBPA treatment alone exerted a stimulatory effect on tadpole growth and brain development at these stages, in parallel with a lack of TH signaling activation, suggesting the involvement of other signaling pathways. As expected, at the metamorphic climax, we observed inhibitory effects of 50-500 nmol/L TBBPA on metamorphic development and brain development, which was in agreement with the antagonistic effects of higher concentrations on T3-induced brain development at premetamorphic stages. Taken together, all results demonstrate that TBBPA can disturb TH signaling and subsequently interfere with TH-dependent brain development in Xenopus; meanwhile, other signaling pathways besides TH signaling could be involved in this process. Our study improves the understanding of the effects of TBBPA on vertebrate brain development. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47626]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qin, Zhanfen |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Mengqi,Li, Yuanyuan,Zhu, Min,et al. Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis[J]. MOLECULES,2022,27(1):249. |
| APA | Dong, Mengqi,Li, Yuanyuan,Zhu, Min,Li, Jinbo,&Qin, Zhanfen.(2022).Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis.MOLECULES,27(1),249. |
| MLA | Dong, Mengqi,et al."Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis".MOLECULES 27.1(2022):249. |
入库方式： OAI收割
来源：生态环境研究中心
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