Tetrabromobisphenol A perturbs cell fate decisions via BMP signaling in the early embryonic development of zebrafish
文献类型：期刊论文
| 作者 | Pang, Shaochen; Gao, Yue ; Wang, Yanwu; Yao, Xinglei; Cao, Mengxi; Liang, Yong; Song, Maoyong; Jiang, Guibin
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2022-05-15 |
| 卷号 | 430期号:0页码:128512 |
| ISSN号 | 0304-3894 |
| 关键词 | BROMINATED FLAME RETARDANTS TBBPA ANTEROPOSTERIOR CHINA MODEL FOOD WNT |
| 英文摘要 | Tetrabromobisphenol A (TBBPA) readily accumulates in the egg yolk of aquatic oviparous animals and is transferred to their embryos. Early embryogenesis is vital for organ formation and subsequent develop-ment. The developmental toxicity of TBBPA in aquatic animals has been extensively reported. However, few studies have assessed the toxic effects of TBBPA in the early embryonic development. In this work, we found that TBBPA perturbed cell fate decisions along the dorsal-ventral (DV) axis during gastrulation, further disrupting early organogenesis in the entire embryo. TBBPA exposure increased the number of embryonic cells that acquired a ventral cell fate, which formed epidermis, blood and heart tissues. In return, the number of embryonic cells that acquired a dorsal cell fate was greatly decreased, causing the TBBPA-exposed embryos to develop a small brain and small eyes. We revealed that TBBPA elevated the activity gradient of bone morphogenetic protein (BMP) signaling which is responsible for cell fate speci-fication along the DV axis, with up-regulation of BMP ligands (bmp4, bmp7a) and target genes (szl) and promotion signal transduction through phosphorylation of Smad1/5. As the function of BMP signaling in embryogenesis is highly conserved among many vertebrates, these findings highlight the ecological and health risks of TBBPA. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47627]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Jianghan Univ, Sch Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China 5.Wuhan Univ, Sch Basic Med Sci, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pang, Shaochen,Gao, Yue,Wang, Yanwu,et al. Tetrabromobisphenol A perturbs cell fate decisions via BMP signaling in the early embryonic development of zebrafish[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,430(0):128512. |
| APA | Pang, Shaochen.,Gao, Yue.,Wang, Yanwu.,Yao, Xinglei.,Cao, Mengxi.,...&Jiang, Guibin.(2022).Tetrabromobisphenol A perturbs cell fate decisions via BMP signaling in the early embryonic development of zebrafish.JOURNAL OF HAZARDOUS MATERIALS,430(0),128512. |
| MLA | Pang, Shaochen,et al."Tetrabromobisphenol A perturbs cell fate decisions via BMP signaling in the early embryonic development of zebrafish".JOURNAL OF HAZARDOUS MATERIALS 430.0(2022):128512. |
入库方式： OAI收割
来源：生态环境研究中心
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