Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test
文献类型：期刊论文
| 作者 | Xiong, Yiming ; Chen, Xuanyue; Li, Feng; Chen, Zhaojing; Qin, Zhanfen
|
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2022-05 |
| 卷号 | 246期号:0页码:106143 |
| ISSN号 | 0166-445X |
| 关键词 | BRACHYDANIO-RERIO RAINBOW-TROUT SALMO-GAIRDNERI BISPHENOL-A EMBRYO CHEMICALS TEBUCONAZOLE PESTICIDES PREDICTION CHLORIDE |
| 英文摘要 | Aquatic toxicity is a mandatory component in risk assessment of chemicals. The currently recommended used acute fish toxicity (AFT) test requires a large test system, bringing onerous experimental operation and discharge of much experimental wastewater. In this study, we established a more convenient and efficient test defined as the zebrafish larvae acute toxicity (FLT) test, which employed zebrafish larvae at four days post fertilization as the test organisms and implemented a 48-hour exposure in 6-well plates. Based on validated reproducibility, we applied this test to evaluate the acute toxicity of 35 chemicals. By comparing the results with the existing acute toxicity data reported in the literature, we found that most chemicals exhibited highly positive correlated LC50 in the FLT and the AFT test, with the same or similar toxicity grade. The FLT test showed more comparable sensitivity with the current AFT test than the previously recommended fish embryo acute toxicity test (FET). Moreover, the FLT test is easier to implement than the FET test which requires microscopic observation to identify the fertilization and development status of the embryos. Despite a limitation similar to the FET test in terms of detecting neurotoxicants, the FLT test could be a more promising alternative to the AFT test relative to the FET test. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/47645]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 通讯作者 | Qin, Zhanfen |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, 18 Shuangqing Rd,POB 2871, Beijing 100085, Peoples R China 2.Univ Toronto, Toronto, ON, Canada 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Hebei Key Lab Wetland Ecol & Conservat, Hengshui 053000, Hebei, Peoples R China 5.Hengshui Univ, Dept Life Sci, 1088 Heping West Rd, Hengshui 053000, Hebei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Yiming,Chen, Xuanyue,Li, Feng,et al. Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test[J]. AQUATIC TOXICOLOGY,2022,246(0):106143. |
| APA | Xiong, Yiming,Chen, Xuanyue,Li, Feng,Chen, Zhaojing,&Qin, Zhanfen.(2022).Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test.AQUATIC TOXICOLOGY,246(0),106143. |
| MLA | Xiong, Yiming,et al."Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test".AQUATIC TOXICOLOGY 246.0(2022):106143. |
入库方式： OAI收割
来源：生态环境研究中心
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