Abnormal neural differentiation in response to graphene quantum dots through histone modification interference
文献类型：期刊论文
| 作者 | Ku, Tingting; Ren, Zhihua; Yang, Renjun ; Liu, Qian S.; Sang, Nan; Faiola, Francesco; Zhou, Qunfang; Jiang, Guibin
|
| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2022 |
| 卷号 | 170页码:107572-1-9 |
| 关键词 | Graphene quantum dots Embryonic stem cells Neural differentiation BMP signaling pathway Histone modification |
| ISSN号 | 0160-4120 |
| 英文摘要 | Graphene quantum dots (GQDs) have been broadly applied in biomedicine in recent years, and their environ-mental exposure and toxicological impacts have raised increasing concerns. The nanosafety assessment on the nervous system is one of the most important aspects, and potential effects of GQDs on neurodevelopment and the underlying mechanism are still elusive. In this study, the neural developmental toxicities of OH-GQDs and NH2- GQDs were investigated using the mouse embryonic stem cells (mESCs). The results revealed that OH-GQDs significantly inhibited the ectoderm development, and reduced the neural precursor formation and neuro-genesis during the neural differentiation of the mESCs. The exploration on the mechanism uncovered that the increased enrichment of H3K27me3 at the promoter region of the Smad6 gene was involved in histone modification-activated BMP signal pathway, which consequently influenced its regulatory effects on neural differentiation. Additionally, OH-GQDs elicited a stronger effect on inducing the imbalance of histone modifi-cation, and resulted in higher latency of neural differentiation disturbance than did NH2-GQDs, suggesting surface functionalization-specific effects of GQDs on neurodevelopmental toxicity. This study would provide new insights in not only the adverse effects of GQDs on neurodevelopment, but also the influence from the chemical modification of GQDs on their bioactivities. |
| 源URL | [https://ir.rcees.ac.cn/handle/311016/48473]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 作者单位 | 1.Chinese Academy of Sciences 2.Research Center for Eco-Environmental Sciences (RCEES) 3.Shanxi University 4.University of Chinese Academy of Sciences, CAS 5.Jianghan University |
| 推荐引用方式 GB/T 7714 | Ku, Tingting,Ren, Zhihua,Yang, Renjun,et al. Abnormal neural differentiation in response to graphene quantum dots through histone modification interference[J]. ENVIRONMENT INTERNATIONAL,2022,170:107572-1-9. |
| APA | Ku, Tingting.,Ren, Zhihua.,Yang, Renjun.,Liu, Qian S..,Sang, Nan.,...&Jiang, Guibin.(2022).Abnormal neural differentiation in response to graphene quantum dots through histone modification interference.ENVIRONMENT INTERNATIONAL,170,107572-1-9. |
| MLA | Ku, Tingting,et al."Abnormal neural differentiation in response to graphene quantum dots through histone modification interference".ENVIRONMENT INTERNATIONAL 170(2022):107572-1-9. |
入库方式： OAI收割
来源：生态环境研究中心
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